Nelson C - Search Results

1

Evaluation of the potential for pharmacokinetic interaction between tirabrutinib and levonorgestrel/ethinyl estradiol in healthy female volunteers.

Cherala G, Nelson C, Guo Y, Mathur A, Tarnowski T, Othman AA. Cherala G, et al. Among authors: nelson c. Clin Transl Sci. 2022 Jun;15(6):1492-1499. doi: 10.1111/cts.13265. Epub 2022 Mar 28. Clin Transl Sci. 2022. PMID: 35266297 Free PMC article.

2

Pharmacokinetics, Safety, and Tolerability of Selonsertib, an Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitor, Following First-in-Human Single and Multiple Ascending Doses in Healthy Subjects.

Nelson CH, Etchevers K, Yi S, Breckenridge D, Hepner M, Patel U, Ling J, Mathias A. Nelson CH, et al. Clin Pharmacokinet. 2020 Sep;59(9):1109-1117. doi: 10.1007/s40262-020-00878-y. Clin Pharmacokinet. 2020. PMID: 32333325 Clinical Trial.

3

Assessment of the Effect of Filgotinib on the Pharmacokinetics of Atorvastatin, Pravastatin, and Rosuvastatin in Healthy Adult Participants.

Anderson K, Nelson CH, Gong Q, Alani M, Tarnowski T, Othman AA. Anderson K, et al. Clin Pharmacol Drug Dev. 2022 Feb;11(2):235-245. doi: 10.1002/cpdd.1015. Epub 2021 Sep 1. Clin Pharmacol Drug Dev. 2022. PMID: 34468080 Free PMC article. Clinical Trial.

4

Semi-Mechanistic PK/PD Modeling and Simulation of Irreversible BTK Inhibition to Support Dose Selection of Tirabrutinib in Subjects with RA.

Meng A, Humeniuk R, Jürgensmeier JM, Hsueh CH, Matzkies F, Grant E, Truong H, Billin AN, Yu H, Feng J, Kwan E, Tarnowski T, Nelson CH. Meng A, et al. Clin Pharmacol Ther. 2022 Feb;111(2):416-424. doi: 10.1002/cpt.2439. Epub 2021 Oct 27. Clin Pharmacol Ther. 2022. PMID: 34623640 Free PMC article.

5

Effect of Renal Impairment on the Pharmacokinetics of Firsocostat, an Acetyl-Coenzyme A Carboxylase Inhibitor, and Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor Agonist.

Weber E, Younis IR, Nelson C, Ding D, Qin A, Xiao D, Watkins TR, Othman AA. Weber E, et al. Among authors: nelson c. J Clin Pharmacol. 2023 May;63(5):560-568. doi: 10.1002/jcph.2206. Epub 2023 Feb 28. J Clin Pharmacol. 2023. PMID: 36700458 Clinical Trial.

6

Evaluation of the Potential for Cytochrome P450 and Transporter-Mediated Drug-Drug Interactions for Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor (FXR) Agonist.

Younis I, Weber E, Nelson C, Kirby BJ, Shen G, Xiao D, Watkins TR, Othman AA. Younis I, et al. Among authors: nelson c. Clin Pharmacokinet. 2023 Apr;62(4):609-621. doi: 10.1007/s40262-023-01214-w. Epub 2023 Mar 11. Clin Pharmacokinet. 2023. PMID: 36906733 Free PMC article.

7

Effect of Hepatic Impairment on the Pharmacokinetics and Pharmacodynamics of Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor Agonist.

Younis IR, Hsueh CH, Nelson C, Billin AN, Yue MS, Xiao D, Watkins TR, Othman AA. Younis IR, et al. Among authors: nelson c. J Clin Pharmacol. 2023 Sep;63(9):1017-1025. doi: 10.1002/jcph.2260. Epub 2023 Jun 7. J Clin Pharmacol. 2023. PMID: 37128693

8

Pharmacokinetics and Safety of Firsocostat, an Acetyl-Coenzyme A Carboxylase Inhibitor, in Participants with Mild, Moderate, and Severe Hepatic Impairment.

Younis IR, Nelson C, Weber EJ, Qin AR, Watkins TR, Othman AA. Younis IR, et al. Among authors: nelson c. J Clin Pharmacol. 2024 Jul;64(7):878-886. doi: 10.1002/jcph.2427. Epub 2024 Mar 22. J Clin Pharmacol. 2024. PMID: 38520128 Clinical Trial.

9

Pharmacokinetics and Safety of Cilofexor and Firsocostat in Healthy Japanese and Non-Japanese Participants.

Younis IR, Nelson C, Weber EJ, Shen G, Qin AR, Xiao D, Watkins TR, Othman AA. Younis IR, et al. Among authors: nelson c. J Clin Pharmacol. 2024 Dec;64(12):1586-1593. doi: 10.1002/jcph.6114. Epub 2024 Aug 30. J Clin Pharmacol. 2024. PMID: 39213138 Clinical Trial.

10

A Quantitative Framework to Evaluate Proarrhythmic Risk in a First-in-Human Study to Support Waiver of a Thorough QT Study.

Nelson CH, Wang L, Fang L, Weng W, Cheng F, Hepner M, Lin J, Garnett C, Ramanathan S. Nelson CH, et al. Clin Pharmacol Ther. 2015 Dec;98(6):630-8. doi: 10.1002/cpt.204. Epub 2015 Sep 29. Clin Pharmacol Ther. 2015. PMID: 26259519 Clinical Trial.

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