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The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity.
Hage A, Bharaj P, van Tol S, Giraldo MI, Gonzalez-Orozco M, Valerdi KM, Warren AN, Aguilera-Aguirre L, Xie X, Widen SG, Moulton HM, Lee B, Johnson JR, Krogan NJ, García-Sastre A, Shi PY, Freiberg AN, Rajsbaum R. Hage A, et al. Among authors: widen sg. Cell Rep. 2022 Mar 8;38(10):110434. doi: 10.1016/j.celrep.2022.110434. Cell Rep. 2022. PMID: 35263596 Free PMC article.
Whole transcriptome analysis reveals an 8-oxoguanine DNA glycosylase-1-driven DNA repair-dependent gene expression linked to essential biological processes.
Aguilera-Aguirre L, Hosoki K, Bacsi A, Radák Z, Wood TG, Widen SG, Sur S, Ameredes BT, Saavedra-Molina A, Brasier AR, Ba X, Boldogh I. Aguilera-Aguirre L, et al. Among authors: widen sg. Free Radic Biol Med. 2015 Apr;81:107-18. doi: 10.1016/j.freeradbiomed.2015.01.004. Epub 2015 Jan 19. Free Radic Biol Med. 2015. PMID: 25614460 Free PMC article.
Differential Responses of Human Fetal Brain Neural Stem Cells to Zika Virus Infection.
McGrath EL, Rossi SL, Gao J, Widen SG, Grant AC, Dunn TJ, Azar SR, Roundy CM, Xiong Y, Prusak DJ, Loucas BD, Wood TG, Yu Y, Fernández-Salas I, Weaver SC, Vasilakis N, Wu P. McGrath EL, et al. Among authors: widen sg. Stem Cell Reports. 2017 Mar 14;8(3):715-727. doi: 10.1016/j.stemcr.2017.01.008. Epub 2017 Feb 16. Stem Cell Reports. 2017. PMID: 28216147 Free PMC article.
Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk.
Galarza-Muñoz G, Briggs FBS, Evsyukova I, Schott-Lerner G, Kennedy EM, Nyanhete T, Wang L, Bergamaschi L, Widen SG, Tomaras GD, Ko DC, Bradrick SS, Barcellos LF, Gregory SG, Garcia-Blanco MA. Galarza-Muñoz G, et al. Among authors: widen sg. Cell. 2017 Mar 23;169(1):72-84.e13. doi: 10.1016/j.cell.2017.03.007. Cell. 2017. PMID: 28340352 Free PMC article.
The N501Y spike substitution enhances SARS-CoV-2 infection and transmission.
Liu Y, Liu J, Plante KS, Plante JA, Xie X, Zhang X, Ku Z, An Z, Scharton D, Schindewolf C, Widen SG, Menachery VD, Shi PY, Weaver SC. Liu Y, et al. Among authors: widen sg. Nature. 2022 Feb;602(7896):294-299. doi: 10.1038/s41586-021-04245-0. Epub 2021 Nov 24. Nature. 2022. PMID: 34818667 Free PMC article.
A single intranasal dose of human parainfluenza virus type 3-vectored vaccine induces effective antibody and memory T cell response in the lungs and protects hamsters against SARS-CoV-2.
Ilinykh PA, Periasamy S, Huang K, Kuzmina NA, Ramanathan P, Meyer MN, Mire CE, Kuzmin IV, Bharaj P, Endsley JR, Chikina M, Sealfon SC, Widen SG, Endsley MA, Bukreyev A. Ilinykh PA, et al. Among authors: widen sg. NPJ Vaccines. 2022 Apr 25;7(1):47. doi: 10.1038/s41541-022-00471-3. NPJ Vaccines. 2022. PMID: 35468973 Free PMC article.
Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant.
Liu Y, Liu J, Johnson BA, Xia H, Ku Z, Schindewolf C, Widen SG, An Z, Weaver SC, Menachery VD, Xie X, Shi PY. Liu Y, et al. Among authors: widen sg. Cell Rep. 2022 May 17;39(7):110829. doi: 10.1016/j.celrep.2022.110829. Epub 2022 Apr 29. Cell Rep. 2022. PMID: 35550680 Free PMC article.
128 results