Liu L - Search Results

1

Accurate positioning of functional residues with robotics-inspired computational protein design.

Krivacic C, Kundert K, Pan X, Pache RA, Liu L, Conchúir SO, Jeliazkov JR, Gray JJ, Thompson MC, Fraser JS, Kortemme T. Krivacic C, et al. Among authors: liu l. Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2115480119. doi: 10.1073/pnas.2115480119. Epub 2022 Mar 7. Proc Natl Acad Sci U S A. 2022. PMID: 35254891 Free PMC article.

2

Expanding the space of protein geometries by computational design of de novo fold families.

Pan X, Thompson MC, Zhang Y, Liu L, Fraser JS, Kelly MJS, Kortemme T. Pan X, et al. Among authors: liu l. Science. 2020 Aug 28;369(6507):1132-1136. doi: 10.1126/science.abc0881. Science. 2020. PMID: 32855341 Free PMC article.

3

Measuring and modeling diffuse scattering in protein X-ray crystallography.

Van Benschoten AH, Liu L, Gonzalez A, Brewster AS, Sauter NK, Fraser JS, Wall ME. Van Benschoten AH, et al. Among authors: liu l. Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4069-74. doi: 10.1073/pnas.1524048113. Epub 2016 Mar 28. Proc Natl Acad Sci U S A. 2016. PMID: 27035972 Free PMC article.

4

Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico.

Broom A, Rakotoharisoa RV, Thompson MC, Zarifi N, Nguyen E, Mukhametzhanov N, Liu L, Fraser JS, Chica RA. Broom A, et al. Among authors: liu l. Nat Commun. 2020 Sep 23;11(1):4808. doi: 10.1038/s41467-020-18619-x. Nat Commun. 2020. PMID: 32968058 Free PMC article.

5

Differences in the chitinolytic activity of mammalian chitinases on soluble and insoluble substrates.

Barad BA, Liu L, Diaz RE, Basilio R, Van Dyken SJ, Locksley RM, Fraser JS. Barad BA, et al. Among authors: liu l. Protein Sci. 2020 Apr;29(4):966-977. doi: 10.1002/pro.3822. Epub 2020 Jan 21. Protein Sci. 2020. PMID: 31930591 Free PMC article.

6

Rescue of conformational dynamics in enzyme catalysis by directed evolution.

Otten R, Liu L, Kenner LR, Clarkson MW, Mavor D, Tawfik DS, Kern D, Fraser JS. Otten R, et al. Among authors: liu l. Nat Commun. 2018 Apr 3;9(1):1314. doi: 10.1038/s41467-018-03562-9. Nat Commun. 2018. PMID: 29615624 Free PMC article.

7

Association between airway microbiota and systemic inflammation markers in non-small cell lung cancer patients.

Huang D, Ren Q, Xie L, Chen Y, Li C, Su X, Lin L, Liu L, Zhao H, Luo T, Wu J, Cai S, Dong H. Huang D, et al. Among authors: liu l. Sci Rep. 2025 Jan 28;15(1):3539. doi: 10.1038/s41598-025-86231-4. Sci Rep. 2025. PMID: 39875410

8

Neoadjuvant pyrotinib and trastuzumab in HER2-positive breast cancer with no early response (NeoPaTHer): efficacy, safety and biomarker analysis of a prospective, multicentre, response-adapted study.

Wang F, Wang Y, Xiong B, Yang Z, Wang J, Yao Y, Yu L, Fu Q, Li L, Zhang Q, Zheng C, Huang S, Liu L, Liu C, Sun H, Mao B, Liu DX, Yu Z. Wang F, et al. Among authors: liu l. Signal Transduct Target Ther. 2025 Jan 29;10(1):45. doi: 10.1038/s41392-025-02138-6. Signal Transduct Target Ther. 2025. PMID: 39875376

9

Micropeptide hSPAR regulates glutamine levels and suppresses mammary tumor growth via a TRIM21-P27KIP1-mTOR axis.

Huang Y, Lu H, Liu Y, Wang J, Xia Q, Shi X, Jin Y, Liang X, Wang W, Ma X, Wang Y, Gong M, Li C, Cang C, Cui Q, Chen C, Shen T, Liu L, Wang X. Huang Y, et al. Among authors: liu l. EMBO J. 2025 Jan 28. doi: 10.1038/s44318-024-00359-z. Online ahead of print. EMBO J. 2025. PMID: 39875724

10

Skull bone marrow and skull meninges channels: redefining the landscape of central nervous system immune surveillance.

Liu L, Zhang X, Chai Y, Zhang J, Deng Q, Chen X. Liu L, et al. Cell Death Dis. 2025 Jan 29;16(1):53. doi: 10.1038/s41419-025-07336-2. Cell Death Dis. 2025. PMID: 39875352 Review.

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