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Page 1
Genomic and Single-Cell Landscape Reveals Novel Drivers and Therapeutic Vulnerabilities of Transformed Cutaneous T-cell Lymphoma.
Song X, Chang S, Seminario-Vidal L, de Mingo Pulido A, Tordesillas L, Song X, Reed RA, Harkins A, Whiddon S, Nguyen JV, Segura CM, Zhang C, Yoder S, Sayegh Z, Zhao Y, Messina JL, Harro CM, Zhang X, Conejo-Garcia JR, Berglund A, Sokol L, Zhang J, Rodriguez PC, Mulé JJ, Futreal AP, Tsai KY, Chen PL. Song X, et al. Among authors: rodriguez pc. Cancer Discov. 2022 May 2;12(5):1294-1313. doi: 10.1158/2159-8290.CD-21-1207. Cancer Discov. 2022. PMID: 35247891 Free PMC article.
IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity.
Song M, Sandoval TA, Chae CS, Chopra S, Tan C, Rutkowski MR, Raundhal M, Chaurio RA, Payne KK, Konrad C, Bettigole SE, Shin HR, Crowley MJP, Cerliani JP, Kossenkov AV, Motorykin I, Zhang S, Manfredi G, Zamarin D, Holcomb K, Rodriguez PC, Rabinovich GA, Conejo-Garcia JR, Glimcher LH, Cubillos-Ruiz JR. Song M, et al. Among authors: rodriguez pc. Nature. 2018 Oct;562(7727):423-428. doi: 10.1038/s41586-018-0597-x. Epub 2018 Oct 10. Nature. 2018. PMID: 30305738 Free PMC article.
Inhibition of Human Dendritic Cell ER Stress Response Reduces T Cell Alloreactivity Yet Spares Donor Anti-tumor Immunity.
Betts BC, Locke FL, Sagatys EM, Pidala J, Walton K, Menges M, Reff J, Saha A, Djeu JY, Kiluk JV, Lee MC, Kim J, Kang CW, Tang CH, Frieling J, Lynch CC, List A, Rodriguez PC, Blazar BR, Conejo-Garcia JR, Del Valle JR, Hu CC, Anasetti C. Betts BC, et al. Among authors: rodriguez pc. Front Immunol. 2018 Dec 6;9:2887. doi: 10.3389/fimmu.2018.02887. eCollection 2018. Front Immunol. 2018. PMID: 30574153 Free PMC article.
ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.
Cao Y, Trillo-Tinoco J, Sierra RA, Anadon C, Dai W, Mohamed E, Cen L, Costich TL, Magliocco A, Marchion D, Klar R, Michel S, Jaschinski F, Reich RR, Mehrotra S, Cubillos-Ruiz JR, Munn DH, Conejo-Garcia JR, Rodriguez PC. Cao Y, et al. Among authors: rodriguez pc. Nat Commun. 2019 Mar 20;10(1):1280. doi: 10.1038/s41467-019-09263-1. Nat Commun. 2019. PMID: 30894532 Free PMC article.
AMPK Alpha-1 Intrinsically Regulates the Function and Differentiation of Tumor Myeloid-Derived Suppressor Cells.
Trillo-Tinoco J, Sierra RA, Mohamed E, Cao Y, de Mingo-Pulido Á, Gilvary DL, Anadon CM, Costich TL, Wei S, Flores ER, Ruffell B, Conejo-Garcia JR, Rodriguez PC. Trillo-Tinoco J, et al. Among authors: rodriguez pc. Cancer Res. 2019 Oct 1;79(19):5034-5047. doi: 10.1158/0008-5472.CAN-19-0880. Epub 2019 Aug 13. Cancer Res. 2019. PMID: 31409640 Free PMC article.
c-Maf: a bad influence in the education of macrophages.
Conejo-Garcia JR, Rodriguez PC. Conejo-Garcia JR, et al. Among authors: rodriguez pc. J Clin Invest. 2020 Apr 1;130(4):1629-1631. doi: 10.1172/JCI135444. J Clin Invest. 2020. PMID: 32175921 Free PMC article.
The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling.
Mohamed E, Sierra RA, Trillo-Tinoco J, Cao Y, Innamarato P, Payne KK, de Mingo Pulido A, Mandula J, Zhang S, Thevenot P, Biswas S, Abdalla SK, Costich TL, Hänggi K, Anadon CM, Flores ER, Haura EB, Mehrotra S, Pilon-Thomas S, Ruffell B, Munn DH, Cubillos-Ruiz JR, Conejo-Garcia JR, Rodriguez PC. Mohamed E, et al. Among authors: rodriguez pc. Immunity. 2020 Apr 14;52(4):668-682.e7. doi: 10.1016/j.immuni.2020.03.004. Immunity. 2020. PMID: 32294407 Free PMC article.
Kindlin-3 gives patrolling monocytes a strong grip.
Conejo-Garcia JR, Rodriguez PC. Conejo-Garcia JR, et al. Among authors: rodriguez pc. J Leukoc Biol. 2020 Jun;107(6):879-881. doi: 10.1002/JLB.3CE0320-168. J Leukoc Biol. 2020. PMID: 32533639 Free PMC article.
BTN3A1 governs antitumor responses by coordinating αβ and γδ T cells.
Payne KK, Mine JA, Biswas S, Chaurio RA, Perales-Puchalt A, Anadon CM, Costich TL, Harro CM, Walrath J, Ming Q, Tcyganov E, Buras AL, Rigolizzo KE, Mandal G, Lajoie J, Ophir M, Tchou J, Marchion D, Luca VC, Bobrowicz P, McLaughlin B, Eskiocak U, Schmidt M, Cubillos-Ruiz JR, Rodriguez PC, Gabrilovich DI, Conejo-Garcia JR. Payne KK, et al. Among authors: rodriguez pc. Science. 2020 Aug 21;369(6506):942-949. doi: 10.1126/science.aay2767. Science. 2020. PMID: 32820120 Free PMC article.
Methyltransferase inhibitors restore SATB1 protective activity against cutaneous T cell lymphoma in mice.
Harro CM, Perez-Sanz J, Costich TL, Payne KK, Anadon CM, Chaurio RA, Biswas S, Mandal G, Rigolizzo KE, Sprenger KB, Mine JA, Showe LC, Yu X, Liu K, Rodriguez PC, Pinilla-Ibarz J, Sokol L, Conejo-Garcia JR. Harro CM, et al. Among authors: rodriguez pc. J Clin Invest. 2021 Feb 1;131(3):e135711. doi: 10.1172/JCI135711. J Clin Invest. 2021. PMID: 33270606 Free PMC article.
155 results