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Stabilized cyclopropane analogs of the splicing inhibitor FD-895.
Villa R, Kashyap MK, Kumar D, Kipps TJ, Castro JE, La Clair JJ, Burkart MD. Villa R, et al. Among authors: kashyap mk. J Med Chem. 2013 Sep 12;56(17):6576-82. doi: 10.1021/jm400861t. Epub 2013 Aug 21. J Med Chem. 2013. PMID: 23919277 Free PMC article.
Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway.
Kashyap MK, Kumar D, Jones H, Amaya-Chanaga CI, Choi MY, Melo-Cardenas J, Ale-Ali A, Kuhne MR, Sabbatini P, Cohen LJ, Shelat SG, Rassenti LZ, Kipps TJ, Cardarelli PM, Castro JE. Kashyap MK, et al. Oncotarget. 2016 Jan 19;7(3):2809-22. doi: 10.18632/oncotarget.6465. Oncotarget. 2016. PMID: 26646452 Free PMC article.
A Carbohydrate-Derived Splice Modulator.
Dhar S, La Clair JJ, León B, Hammons JC, Yu Z, Kashyap MK, Castro JE, Burkart MD. Dhar S, et al. Among authors: kashyap mk. J Am Chem Soc. 2016 Apr 20;138(15):5063-8. doi: 10.1021/jacs.5b13427. Epub 2016 Apr 8. J Am Chem Soc. 2016. PMID: 27058259
Selectivity in Small Molecule Splicing Modulation.
Kumar D, Kashyap MK, La Clair JJ, Villa R, Spaanderman I, Chien S, Rassenti LZ, Kipps TJ, Burkart MD, Castro JE. Kumar D, et al. Among authors: kashyap mk. ACS Chem Biol. 2016 Oct 21;11(10):2716-2723. doi: 10.1021/acschembio.6b00399. Epub 2016 Aug 8. ACS Chem Biol. 2016. PMID: 27499047
A Challenging Pie to Splice: Drugging the Spliceosome.
León B, Kashyap MK, Chan WC, Krug KA, Castro JE, La Clair JJ, Burkart MD. León B, et al. Among authors: kashyap mk. Angew Chem Int Ed Engl. 2017 Sep 25;56(40):12052-12063. doi: 10.1002/anie.201701065. Epub 2017 Aug 15. Angew Chem Int Ed Engl. 2017. PMID: 28371109 Free PMC article. Review.
Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia.
Kashyap MK, Amaya-Chanaga CI, Kumar D, Simmons B, Huser N, Gu Y, Hallin M, Lindquist K, Yafawi R, Choi MY, Amine AA, Rassenti LZ, Zhang C, Liu SH, Smeal T, Fantin VR, Kipps TJ, Pernasetti F, Castro JE. Kashyap MK, et al. J Hematol Oncol. 2017 May 19;10(1):112. doi: 10.1186/s13045-017-0435-x. J Hematol Oncol. 2017. PMID: 28526063 Free PMC article.
70 results