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The ChAdOx1 vectored vaccine, AZD2816, induces strong immunogenicity against SARS-CoV-2 beta (B.1.351) and other variants of concern in preclinical studies.
Spencer AJ, Morris S, Ulaszewska M, Powers C, Kailath R, Bissett C, Truby A, Thakur N, Newman J, Allen ER, Rudiansyah I, Liu C, Dejnirattisai W, Mongkolsapaya J, Davies H, Donnellan FR, Pulido D, Peacock TP, Barclay WS, Bright H, Ren K, Screaton G, McTamney P, Bailey D, Gilbert SC, Lambe T. Spencer AJ, et al. Among authors: bright h. EBioMedicine. 2022 Mar;77:103902. doi: 10.1016/j.ebiom.2022.103902. Epub 2022 Feb 26. EBioMedicine. 2022. PMID: 35228013 Free PMC article.
The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans.
Loo YM, McTamney PM, Arends RH, Abram ME, Aksyuk AA, Diallo S, Flores DJ, Kelly EJ, Ren K, Roque R, Rosenthal K, Streicher K, Tuffy KM, Bond NJ, Cornwell O, Bouquet J, Cheng LI, Dunyak J, Huang Y, Rosenbaum AI, Pilla Reddy V, Andersen H, Carnahan RH, Crowe JE Jr, Kuehne AI, Herbert AS, Dye JM, Bright H, Kallewaard NL, Pangalos MN, Esser MT. Loo YM, et al. Among authors: bright h. Sci Transl Med. 2022 Mar 9;14(635):eabl8124. doi: 10.1126/scitranslmed.abl8124. Epub 2022 Mar 9. Sci Transl Med. 2022. PMID: 35076282 Free PMC article.
Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail.
Dong J, Zost SJ, Greaney AJ, Starr TN, Dingens AS, Chen EC, Chen RE, Case JB, Sutton RE, Gilchuk P, Rodriguez J, Armstrong E, Gainza C, Nargi RS, Binshtein E, Xie X, Zhang X, Shi PY, Logue J, Weston S, McGrath ME, Frieman MB, Brady T, Tuffy KM, Bright H, Loo YM, McTamney PM, Esser MT, Carnahan RH, Diamond MS, Bloom JD, Crowe JE Jr. Dong J, et al. Among authors: bright h. Nat Microbiol. 2021 Oct;6(10):1233-1244. doi: 10.1038/s41564-021-00972-2. Epub 2021 Sep 21. Nat Microbiol. 2021. PMID: 34548634 Free PMC article.
Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail.
Dong J, Zost S, Greaney A, Starr TN, Dingens AS, Chen EC, Chen R, Case B, Sutton R, Gilchuk P, Rodriguez J, Armstrong E, Gainza C, Nargi R, Binshtein E, Xie X, Zhang X, Shi PY, Logue J, Weston S, McGrath M, Frieman M, Brady T, Tuffy K, Bright H, Loo YM, McvTamney P, Esser M, Carnahan R, Diamond M, Bloom J, Crowe JE. Dong J, et al. Among authors: bright h. bioRxiv [Preprint]. 2021 Mar 1:2021.01.27.428529. doi: 10.1101/2021.01.27.428529. bioRxiv. 2021. Update in: Nat Microbiol. 2021 Oct;6(10):1233-1244. doi: 10.1038/s41564-021-00972-2 PMID: 33532768 Free PMC article. Updated. Preprint.
120 results