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PKG II secreted via the classical endoplasmic reticulum-Golgi apparatus secretory pathway blocks the activation of EGFR through phosporalting its threonine 406 and has an anti-tumor effect.
Wu Y, Wu M, Wang Z, Pang J, Zhu M, Lan T, Yao X, Qian H, Lin X, Jiang L, Tao Y, Zhang Y, Chen Y. Wu Y, et al. Among authors: wu m. Front Biosci (Landmark Ed). 2022 Feb 11;27(2):53. doi: 10.31083/j.fbl2702053. Front Biosci (Landmark Ed). 2022. PMID: 35226996 Free article.
PKG II inhibits EGF/EGFR-induced migration of gastric cancer cells.
Jiang L, Lan T, Chen Y, Sang J, Li Y, Wu M, Tao Y, Wang Y, Qian H, Gu L. Jiang L, et al. Among authors: wu m. PLoS One. 2013 Apr 16;8(4):e61674. doi: 10.1371/journal.pone.0061674. Print 2013. PLoS One. 2013. PMID: 23613900 Free PMC article.
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