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The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression.
Wu D, Wang S, Oliveira DV, Del Gaudio F, Vanlandewijck M, Lebouvier T, Betsholtz C, Zhao J, Jin S, Lendahl U, Karlström H. Wu D, et al. Among authors: karlstrom h. Dis Model Mech. 2021 Jan 28;14(2):dmm046300. doi: 10.1242/dmm.046300. Online ahead of print. Dis Model Mech. 2021. PMID: 33509954 Free PMC article.
γ-Secretase modulators show selectivity for γ-secretase-mediated amyloid precursor protein intramembrane processing.
Weber TA, Lundkvist J, Wanngren J, Kvartsberg H, Jin S, Larssen P, Wu D, Oliveira DV, Minta K, Brinkmalm G, Zetterberg H, Blennow K, Nordvall G, Winblad B, Portelius E, Karlström H. Weber TA, et al. Among authors: karlstrom h. J Cell Mol Med. 2022 Feb;26(3):880-892. doi: 10.1111/jcmm.17146. Epub 2021 Dec 20. J Cell Mol Med. 2022. PMID: 34931449 Free PMC article.
Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model.
Oliveira DV, Coupland KG, Shao W, Jin S, Del Gaudio F, Wang S, Fox R, Rutten JW, Sandin J, Zetterberg H, Lundkvist J, Lesnik Oberstein SA, Lendahl U, Karlström H. Oliveira DV, et al. Among authors: karlstrom h. EMBO Mol Med. 2023 Feb 8;15(2):e16556. doi: 10.15252/emmm.202216556. Epub 2022 Dec 16. EMBO Mol Med. 2023. PMID: 36524456 Free PMC article.
Differences in proliferation rate between CADASIL and control vascular smooth muscle cells are related to increased TGFβ expression.
Panahi M, Yousefi Mesri N, Samuelsson EB, Coupland KG, Forsell C, Graff C, Tikka S, Winblad B, Viitanen M, Karlström H, Sundström E, Behbahani H. Panahi M, et al. Among authors: karlstrom h. J Cell Mol Med. 2018 Jun;22(6):3016-3024. doi: 10.1111/jcmm.13534. Epub 2018 Mar 13. J Cell Mol Med. 2018. PMID: 29536621 Free PMC article.
39 results