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Syntheses and evaluation of carbon-11- and fluorine-18-radiolabeled pan-tropomyosin receptor kinase (Trk) inhibitors: exploration of the 4-aza-2-oxindole scaffold as Trk PET imaging agents.
Bernard-Gauthier V, Aliaga A, Aliaga A, Boudjemeline M, Hopewell R, Kostikov A, Rosa-Neto P, Thiel A, Schirrmacher R. Bernard-Gauthier V, et al. Among authors: hopewell r. ACS Chem Neurosci. 2015 Feb 18;6(2):260-76. doi: 10.1021/cn500193f. Epub 2014 Nov 10. ACS Chem Neurosci. 2015. PMID: 25350780
In vivo quantification of neurofibrillary tangles with [18F]MK-6240.
Pascoal TA, Shin M, Kang MS, Chamoun M, Chartrand D, Mathotaarachchi S, Bennacef I, Therriault J, Ng KP, Hopewell R, Bouhachi R, Hsiao HH, Benedet AL, Soucy JP, Massarweh G, Gauthier S, Rosa-Neto P. Pascoal TA, et al. Among authors: hopewell r. Alzheimers Res Ther. 2018 Jul 31;10(1):74. doi: 10.1186/s13195-018-0402-y. Alzheimers Res Ther. 2018. PMID: 30064520 Free PMC article.
A simplified radiosynthesis of [18 F]MK-6240 for tau PET imaging.
Hopewell R, Ross K, Kostikov A, Pascoal TA, Alberti T, Lacatus-Samoila M, Soucy JP, Bennacef I, Kobayashi E, Kang MS, Rosa-Neto P, Massarweh G. Hopewell R, et al. J Labelled Comp Radiopharm. 2019 Feb;62(2):109-114. doi: 10.1002/jlcr.3695. Epub 2018 Dec 19. J Labelled Comp Radiopharm. 2019. PMID: 30426529
18F-MK-6240 PET for early and late detection of neurofibrillary tangles.
Pascoal TA, Therriault J, Benedet AL, Savard M, Lussier FZ, Chamoun M, Tissot C, Qureshi MNI, Kang MS, Mathotaarachchi S, Stevenson J, Hopewell R, Massarweh G, Soucy JP, Gauthier S, Rosa-Neto P. Pascoal TA, et al. Among authors: hopewell r. Brain. 2020 Sep 1;143(9):2818-2830. doi: 10.1093/brain/awaa180. Brain. 2020. PMID: 32671408
48 results