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Blocking cholesterol storage to treat Alzheimer's disease.
Chang TY, Chang CCY, Harned TC, De La Torre AL, Lee J, Huynh TN, Gow JG. Chang TY, et al. Among authors: chang ccy. Explor Neuroprotective Ther. 2021 Dec 30;1(3):173-184. doi: 10.37349/ent.2021.00014. Explor Neuroprotective Ther. 2021. PMID: 35199105 Free PMC article.
Partial blockage of sterol biosynthesis with a squalene synthase inhibitor in early postnatal Niemann-Pick type C npcnih null mice brains reduces neuronal cholesterol accumulation, abrogates astrogliosis, but may inhibit myelin maturation.
Reid PC, Lin S, Vanier MT, Ohno-Iwashita Y, Harwood HJ Jr, Hickey WF, Chang CC, Chang TY. Reid PC, et al. J Neurosci Methods. 2008 Feb 15;168(1):15-25. doi: 10.1016/j.jneumeth.2007.09.002. Epub 2007 Sep 12. J Neurosci Methods. 2008. PMID: 17949821 Free PMC article.
Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage.
Shibuya Y, Niu Z, Bryleva EY, Harris BT, Murphy SR, Kheirollah A, Bowen ZD, Chang CCY, Chang TY. Shibuya Y, et al. Among authors: chang ccy, chang ty. Neurobiol Aging. 2015 Jul;36(7):2248-2259. doi: 10.1016/j.neurobiolaging.2015.04.002. Epub 2015 Apr 7. Neurobiol Aging. 2015. PMID: 25930235 Free PMC article.
Facile method to incorporate high-affinity ACAT/SOAT1 inhibitor F12511 into stealth liposome-based nanoparticle and demonstration of its efficacy in blocking cholesteryl ester biosynthesis without overt toxicity in neuronal cell culture.
De La Torre AL, Smith C, Granger J, Anderson FL, Harned TC, Havrda MC, Chang CCY, Chang TY. De La Torre AL, et al. Among authors: chang ccy. J Neurosci Methods. 2022 Feb 1;367:109437. doi: 10.1016/j.jneumeth.2021.109437. Epub 2021 Dec 7. J Neurosci Methods. 2022. PMID: 34890698 Free PMC article.
Stealth Liposomes Encapsulating a Potent ACAT1/SOAT1 Inhibitor F12511: Pharmacokinetic, Biodistribution, and Toxicity Studies in Wild-Type Mice and Efficacy Studies in Triple Transgenic Alzheimer's Disease Mice.
De La Torre AL, Huynh TN, Chang CCY, Pooler DB, Ness DB, Lewis LD, Pannem S, Feng Y, Samkoe KS, Hickey WF, Chang TY. De La Torre AL, et al. Among authors: chang ccy. Int J Mol Sci. 2023 Jul 2;24(13):11013. doi: 10.3390/ijms241311013. Int J Mol Sci. 2023. PMID: 37446191 Free PMC article.
75 results