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Longitudinal single-cell RNA-seq analysis reveals stress-promoted chemoresistance in metastatic ovarian cancer.
Zhang K, Erkan EP, Jamalzadeh S, Dai J, Andersson N, Kaipio K, Lamminen T, Mansuri N, Huhtinen K, Carpén O, Hietanen S, Oikkonen J, Hynninen J, Virtanen A, Häkkinen A, Hautaniemi S, Vähärautio A. Zhang K, et al. Among authors: hautaniemi s. Sci Adv. 2022 Feb 25;8(8):eabm1831. doi: 10.1126/sciadv.abm1831. Epub 2022 Feb 23. Sci Adv. 2022. PMID: 35196078 Free PMC article.
A Functional Homologous Recombination Assay Predicts Primary Chemotherapy Response and Long-Term Survival in Ovarian Cancer Patients.
Tumiati M, Hietanen S, Hynninen J, Pietilä E, Färkkilä A, Kaipio K, Roering P, Huhtinen K, Alkodsi A, Li Y, Lehtonen R, Erkan EP, Tuominen MM, Lehti K, Hautaniemi SK, Vähärautio A, Grénman S, Carpén O, Kauppi L. Tumiati M, et al. Among authors: hautaniemi sk. Clin Cancer Res. 2018 Sep 15;24(18):4482-4493. doi: 10.1158/1078-0432.CCR-17-3770. Epub 2018 Jun 1. Clin Cancer Res. 2018. PMID: 29858219
Identifying differentially methylated sites in samples with varying tumor purity.
Häkkinen A, Alkodsi A, Facciotto C, Zhang K, Kaipio K, Leppä S, Carpén O, Grénman S, Hynninen J, Hietanen S, Lehtonen R, Hautaniemi S. Häkkinen A, et al. Among authors: hautaniemi s. Bioinformatics. 2018 Sep 15;34(18):3078-3085. doi: 10.1093/bioinformatics/bty310. Bioinformatics. 2018. PMID: 29912358
Anduril 2: upgraded large-scale data integration framework.
Cervera A, Rantanen V, Ovaska K, Laakso M, Nuñez-Fontarnau J, Alkodsi A, Casado J, Facciotto C, Häkkinen A, Louhimo R, Karinen S, Zhang K, Lavikka K, Lyly L, Pal Singh M, Hautaniemi S. Cervera A, et al. Among authors: hautaniemi s. Bioinformatics. 2019 Oct 1;35(19):3815-3817. doi: 10.1093/bioinformatics/btz133. Bioinformatics. 2019. PMID: 30793160
ALDH1A1-related stemness in high-grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR-PI3K/aurora kinase inhibitors.
Kaipio K, Chen P, Roering P, Huhtinen K, Mikkonen P, Östling P, Lehtinen L, Mansuri N, Korpela T, Potdar S, Hynninen J, Auranen A, Grénman S, Wennerberg K, Hautaniemi S, Carpén O. Kaipio K, et al. Among authors: hautaniemi s. J Pathol. 2020 Feb;250(2):159-169. doi: 10.1002/path.5356. Epub 2019 Dec 3. J Pathol. 2020. PMID: 31595974
188 results