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Page 1
Potent Neutralization of Omicron and other SARS-CoV-2 Variants of Concern by Biparatopic Human VH Domains.
Chen C, Saville JW, Marti MM, Schäfer A, Cheng MH, Mannar D, Zhu X, Berezuk AM, Banerjee A, Sobolewski MD, Kim A, Treat BR, Da Silva Castanha PM, Enick N, McCormick KD, Liu X, Adams C, Hines MG, Sun Z, Chen W, Jacobs JL, Barratt-Boyes SM, Mellors JW, Baric RS, Bahar I, Dimitrov DS, Subramaniam S, Martinez DR, Li W. Chen C, et al. Among authors: baric rs. bioRxiv [Preprint]. 2022 Feb 24:2022.02.18.481058. doi: 10.1101/2022.02.18.481058. bioRxiv. 2022. Update in: iScience. 2022 Aug 19;25(8):104798. doi: 10.1016/j.isci.2022.104798 PMID: 35194603 Free PMC article. Updated. Preprint.
Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines.
Walls AC, Miranda MC, Pham MN, Schäfer A, Greaney A, Arunachalam PS, Navarro MJ, Tortorici MA, Rogers K, O'Connor MA, Shireff L, Ferrell DE, Brunette N, Kepl E, Bowen J, Zepeda SK, Starr T, Hsieh CL, Fiala B, Wrenn S, Pettie D, Sydeman C, Johnson M, Blackstone A, Ravichandran R, Ogohara C, Carter L, Tilles SW, Rappuoli R, O'Hagan DT, Van Der Most R, Van Voorhis WC, McLellan JS, Kleanthous H, Sheahan TP, Fuller DH, Villinger F, Bloom J, Pulendran B, Baric R, King N, Veesler D. Walls AC, et al. bioRxiv [Preprint]. 2021 Mar 16:2021.03.15.435528. doi: 10.1101/2021.03.15.435528. bioRxiv. 2021. Update in: Cell. 2021 Oct 14;184(21):5432-5447.e16. doi: 10.1016/j.cell.2021.09.015 PMID: 33758839 Free PMC article. Updated. Preprint.
Common Mechanism of SARS-CoV and SARS-CoV-2 Pathogenesis across Species.
Schäfer A, Gralinski LE, Leist SR, Winkler ES, Hampton BK, Mooney MA, Jensen KL, Graham RL, Agnihothram S, Jeng S, Chamberlin S, Bell TA, Scobey DT, VanBlargan LA, Thackray LB, Hock P, Miller DR, Shaw GD, de Villena FPM, McWeeney SK, Montgomery SA, Diamond MS, Heise MT, Menachery VD, Ferris MT, Baric RS. Schäfer A, et al. Among authors: baric rs. bioRxiv [Preprint]. 2021 May 14:2021.05.14.444205. doi: 10.1101/2021.05.14.444205. bioRxiv. 2021. PMID: 34013261 Free PMC article. Preprint.
Protective efficacy of rhesus adenovirus COVID-19 vaccines against mouse-adapted SARS-CoV-2.
Tostanoski LH, Gralinski LE, Martinez DR, Schaefer A, Mahrokhian SH, Li Z, Nampanya F, Wan H, Yu J, Chang A, Liu J, McMahan K, Dinnon KH, Leist SR, Baric RS, Barouch DH. Tostanoski LH, et al. Among authors: baric rs. bioRxiv [Preprint]. 2021 Jun 15:2021.06.14.448461. doi: 10.1101/2021.06.14.448461. bioRxiv. 2021. Update in: J Virol. 2021 Nov 9;95(23):e0097421. doi: 10.1128/JVI.00974-21 PMID: 34159335 Free PMC article. Updated. Preprint.
Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice.
Schäfer A, Martinez DR, Won JJ, Moreira FR, Brown AJ, Gully KL, Kalla R, Chun K, Du Pont V, Babusis D, Tang J, Murakami E, Subramanian R, Barrett KT, Bleier BJ, Bannister R, Feng JY, Bilello JP, Cihlar T, Mackman RL, Montgomery SA, Baric RS, Sheahan TP. Schäfer A, et al. Among authors: baric rs. bioRxiv [Preprint]. 2021 Sep 17:2021.09.13.460111. doi: 10.1101/2021.09.13.460111. bioRxiv. 2021. Update in: Sci Transl Med. 2022 May 4;14(643):eabm3410. doi: 10.1126/scitranslmed.abm3410 PMID: 34545367 Free PMC article. Updated. Preprint.
Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2.
Yang X, Dickmander RJ, Bayati A, Taft-Benz SA, Smith JL, Wells CI, Madden EA, Brown JW, Lenarcic EM, Yount BL Jr, Chang E, Axtman AD, Baric RS, Heise MT, McPherson PS, Moorman NJ, Willson TM. Yang X, et al. Among authors: baric rs. bioRxiv [Preprint]. 2022 Jan 26:2022.01.03.474779. doi: 10.1101/2022.01.03.474779. bioRxiv. 2022. Update in: ACS Chem Biol. 2022 Jul 15;17(7):1937-1950. doi: 10.1021/acschembio.2c00378 PMID: 35018375 Free PMC article. Updated. Preprint.
Targeted isolation of panels of diverse human protective broadly neutralizing antibodies against SARS-like viruses.
He WT, Musharrafieh R, Song G, Dueker K, Tse LV, Martinez DR, Schäfer A, Callaghan S, Yong P, Beutler N, Torres JL, Volk RM, Zhou P, Yuan M, Liu H, Anzanello F, Capozzola T, Parren M, Garcia E, Rawlings SA, Smith DM, Wilson IA, Safonova Y, Ward AB, Rogers TF, Baric RS, Gralinski LE, Burton DR, Andrabi R. He WT, et al. Among authors: baric rs. bioRxiv [Preprint]. 2022 Feb 8:2021.09.08.459480. doi: 10.1101/2021.09.08.459480. bioRxiv. 2022. Update in: Nat Immunol. 2022 Jun;23(6):960-970. doi: 10.1038/s41590-022-01222-1 PMID: 35169804 Free PMC article. Updated. Preprint.
A model of persistent post SARS-CoV-2 induced lung disease for target identification and testing of therapeutic strategies.
Dinnon KH 3rd, Leist SR, Okuda K, Dang H, Fritch EJ, Gully KL, De la Cruz G, Evangelista MD, Asakura T, Gilmore RC, Hawkins P, Nakano S, West A, Schäfer A, Gralinski LE, Everman JL, Sajuthi SP, Zweigart MR, Dong S, McBride J, Cooley MR, Hines JB, Love MK, Groshong SD, VanSchoiack A, Phelan SJ, Liang Y, Hether T, Leon M, Zumwalt RE, Barton LM, Duval EJ, Mukhopadhyay S, Stroberg E, Borczuk A, Thorne LB, Sakthivel MK, Lee YZ, Hagood JS, Mock JR, Seibold MA, O'Neal WK, Montgomery SA, Boucher RC, Baric RS. Dinnon KH 3rd, et al. Among authors: baric rs. bioRxiv [Preprint]. 2022 Feb 15:2022.02.15.480515. doi: 10.1101/2022.02.15.480515. bioRxiv. 2022. PMID: 35194605 Free PMC article. Preprint.
Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe disease.
Zhou P, Song G, He WT, Beutler N, Tse LV, Martinez DR, Schäfer A, Anzanello F, Yong P, Peng L, Dueker K, Musharrafieh R, Callaghan S, Capozzola T, Yuan M, Liu H, Limbo O, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Jardine JG, Wilson IA, Safonova Y, Rogers TF, Baric RS, Gralinski LE, Burton DR, Andrabi R. Zhou P, et al. Among authors: baric rs. bioRxiv [Preprint]. 2022 Mar 7:2022.03.04.479488. doi: 10.1101/2022.03.04.479488. bioRxiv. 2022. Update in: Immunity. 2023 Mar 14;56(3):669-686.e7. doi: 10.1016/j.immuni.2023.02.005 PMID: 35291291 Free PMC article. Updated. Preprint.
Fc mediated pan-sarbecovirus protection after alphavirus vector vaccination.
Adams LE, Leist SR, Dinnon KH, West A, Gully KL, Anderson EJ, Loome JF, Madden EA, Powers JM, Schäfer A, Sarkar S, Castillo IN, Maron JS, McNamara RP, Bertera HL, Zweigert MR, Higgins JS, Hampton BK, Premkumar L, Alter G, Montgomery SA, Baxter VK, Heise MT, Baric RS. Adams LE, et al. Among authors: baric rs. bioRxiv [Preprint]. 2022 Nov 28:2022.11.28.518175. doi: 10.1101/2022.11.28.518175. bioRxiv. 2022. Update in: Cell Rep. 2023 Apr 25;42(4):112326. doi: 10.1016/j.celrep.2023.112326 PMID: 36482964 Free PMC article. Updated. Preprint.
561 results