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Endogenous Hyperinsulinemia Contributes to Pancreatic Cancer Development.
Zhang AMY, Magrill J, de Winter TJJ, Hu X, Skovsø S, Schaeffer DF, Kopp JL, Johnson JD. Zhang AMY, et al. Cell Metab. 2019 Sep 3;30(3):403-404. doi: 10.1016/j.cmet.2019.07.003. Epub 2019 Aug 1. Cell Metab. 2019. PMID: 31378465 Free article. No abstract available.
Hyperinsulinemia in Obesity, Inflammation, and Cancer.
Zhang AMY, Wellberg EA, Kopp JL, Johnson JD. Zhang AMY, et al. Diabetes Metab J. 2021 May;45(3):285-311. doi: 10.4093/dmj.2020.0250. Epub 2021 Mar 29. Diabetes Metab J. 2021. PMID: 33775061 Free PMC article. Review.
Hyperinsulinemia in Obesity, Inflammation, and Cancer.
Zhang AMY, Wellberg EA, Kopp JL, Johnson JD. Zhang AMY, et al. Diabetes Metab J. 2021 Jul;45(4):622. doi: 10.4093/dmj.2021.0131. Epub 2021 Jul 30. Diabetes Metab J. 2021. PMID: 34352994 Free PMC article. No abstract available.
Breast Cancer Endocrine Therapy Promotes Weight Gain With Distinct Adipose Tissue Effects in Lean and Obese Female Mice.
Scalzo RL, Foright RM, Hull SE, Knaub LA, Johnson-Murguia S, Kinanee F, Kaplan J, Houck JA, Johnson G, Sharp RR, Gillen AE, Jones KL, Zhang AMY, Johnson JD, MacLean PS, Reusch JEB, Wright-Hobart S, Wellberg EA. Scalzo RL, et al. Among authors: zhang amy. Endocrinology. 2021 Nov 1;162(11):bqab174. doi: 10.1210/endocr/bqab174. Endocrinology. 2021. PMID: 34410380 Free PMC article.
Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation.
Zhang AMY, Xia YH, Lin JSH, Chu KH, Wang WCK, Ruiter TJJ, Yang JCC, Chen N, Chhuor J, Patil S, Cen HH, Rideout EJ, Richard VR, Schaeffer DF, Zahedi RP, Borchers CH, Johnson JD, Kopp JL. Zhang AMY, et al. Cell Metab. 2023 Dec 5;35(12):2119-2135.e5. doi: 10.1016/j.cmet.2023.10.003. Epub 2023 Oct 31. Cell Metab. 2023. PMID: 37913768 Free article.
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.
Xu H, Di Antonio M, McKinney S, Mathew V, Ho B, O'Neil NJ, Santos ND, Silvester J, Wei V, Garcia J, Kabeer F, Lai D, Soriano P, Banáth J, Chiu DS, Yap D, Le DD, Ye FB, Zhang A, Thu K, Soong J, Lin SC, Tsai AH, Osako T, Algara T, Saunders DN, Wong J, Xian J, Bally MB, Brenton JD, Brown GW, Shah SP, Cescon D, Mak TW, Caldas C, Stirling PC, Hieter P, Balasubramanian S, Aparicio S. Xu H, et al. Nat Commun. 2017 Feb 17;8:14432. doi: 10.1038/ncomms14432. Nat Commun. 2017. PMID: 28211448 Free PMC article.
184 results