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Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics.
Zhang AMY, Chu KH, Daly BF, Ruiter T, Dou Y, Yang JCC, de Winter TJJ, Chhuor J, Wang S, Flibotte S, Zhao YB, Hu X, Li H, Rideout EJ, Schaeffer DF, Johnson JD, Kopp JL. Zhang AMY, et al. Among authors: schaeffer df. Cancer Metab. 2022 Feb 21;10(1):5. doi: 10.1186/s40170-022-00282-z. Cancer Metab. 2022. PMID: 35189981 Free PMC article.
Loss of Pten and Activation of Kras Synergistically Induce Formation of Intraductal Papillary Mucinous Neoplasia From Pancreatic Ductal Cells in Mice.
Kopp JL, Dubois CL, Schaeffer DF, Samani A, Taghizadeh F, Cowan RW, Rhim AD, Stiles BL, Valasek M, Sander M. Kopp JL, et al. Among authors: schaeffer df. Gastroenterology. 2018 Apr;154(5):1509-1523.e5. doi: 10.1053/j.gastro.2017.12.007. Epub 2017 Dec 19. Gastroenterology. 2018. PMID: 29273451 Free PMC article.
Endogenous Hyperinsulinemia Contributes to Pancreatic Cancer Development.
Zhang AMY, Magrill J, de Winter TJJ, Hu X, Skovsø S, Schaeffer DF, Kopp JL, Johnson JD. Zhang AMY, et al. Among authors: schaeffer df. Cell Metab. 2019 Sep 3;30(3):403-404. doi: 10.1016/j.cmet.2019.07.003. Epub 2019 Aug 1. Cell Metab. 2019. PMID: 31378465 Free article. No abstract available.
Islet amyloid polypeptide does not suppress pancreatic cancer.
Taylor AJ, Panzhinskiy E, Orban PC, Lynn FC, Schaeffer DF, Johnson JD, Kopp JL, Verchere CB. Taylor AJ, et al. Among authors: schaeffer df. Mol Metab. 2023 Feb;68:101667. doi: 10.1016/j.molmet.2023.101667. Epub 2023 Jan 5. Mol Metab. 2023. PMID: 36621763 Free PMC article.
Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation.
Zhang AMY, Xia YH, Lin JSH, Chu KH, Wang WCK, Ruiter TJJ, Yang JCC, Chen N, Chhuor J, Patil S, Cen HH, Rideout EJ, Richard VR, Schaeffer DF, Zahedi RP, Borchers CH, Johnson JD, Kopp JL. Zhang AMY, et al. Among authors: schaeffer df. Cell Metab. 2023 Dec 5;35(12):2119-2135.e5. doi: 10.1016/j.cmet.2023.10.003. Epub 2023 Oct 31. Cell Metab. 2023. PMID: 37913768 Free article.
Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles.
Ali HA, Karasinska JM, Topham JT, Johal D, Kalloger S, Metcalfe A, Warren CS, Miyagi A, Tao LV, Kevorkova M, Chafe SC, McDonald PC, Dedhar S, Parker SJ, Renouf DJ, Schaeffer DF. Ali HA, et al. Among authors: schaeffer df. Cancer Metab. 2024 Oct 3;12(1):28. doi: 10.1186/s40170-024-00357-z. Cancer Metab. 2024. PMID: 39363341 Free PMC article.
166 results