Xu Y - Search Results

1

Incorporating protein precipitation to resolve hybrid IP-LC-MS assay interference for ultrasensitive quantification of intact therapeutic insulin dimer in human plasma.

Sun L, Xu Y, Dube N, Anderson M, Breidinger S, Vaddady P, Thornton B, Morrow L, Matthews RP, Stoch SA, Woolf EJ. Sun L, et al. Among authors: xu y. J Pharm Biomed Anal. 2022 Apr 1;212:114639. doi: 10.1016/j.jpba.2022.114639. Epub 2022 Feb 2. J Pharm Biomed Anal. 2022. PMID: 35176654

2

Determination of sitagliptinin human plasma using protein precipitation and tandem mass spectrometry.

Zeng W, Xu Y, Constanzer M, Woolf EJ. Zeng W, et al. Among authors: xu y. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jul 1;878(21):1817-23. doi: 10.1016/j.jchromb.2010.05.013. Epub 2010 May 12. J Chromatogr B Analyt Technol Biomed Life Sci. 2010. PMID: 20605540

3

Insulin glargine and its two active metabolites: A sensitive (16pM) and robust simultaneous hybrid assay coupling immunoaffinity purification with LC-MS/MS to support biosimilar clinical studies.

Xu Y, Sun L, Anderson M, Bélanger P, Trinh V, Lavallée P, Kantesaria B, Marcoux MJ, Breidinger S, Bateman KP, Goykhman D, Woolf EJ. Xu Y, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 15;1063:50-59. doi: 10.1016/j.jchromb.2017.08.018. Epub 2017 Aug 19. J Chromatogr B Analyt Technol Biomed Life Sci. 2017. PMID: 28846865

4

Extractability-mediated stability bias and hematocrit impact: High extraction recovery is critical to feasibility of volumetric adsorptive microsampling (VAMS) in regulated bioanalysis.

Xie I, Xu Y, Anderson M, Wang M, Xue L, Breidinger S, Goykhman D, Woolf EJ, Bateman KP. Xie I, et al. Among authors: xu y. J Pharm Biomed Anal. 2018 Jul 15;156:58-66. doi: 10.1016/j.jpba.2018.04.001. Epub 2018 Apr 5. J Pharm Biomed Anal. 2018. PMID: 29689469

5

Strategy for peptide quantification using LC-MS in regulated bioanalysis: case study with a glucose-responsive insulin.

Xu Y, Goykhman D, Wang M, Jackson T, Xie I, Willson K, Breidinger S, Schuck H, Harrelson J, Woolf EJ. Xu Y, et al. Bioanalysis. 2018 Aug 1;10(15):1207-1220. doi: 10.4155/bio-2018-0089. Epub 2018 Jul 31. Bioanalysis. 2018. PMID: 30062907

6

Volumetric absorptive microsampling (VAMS®) in therapeutic protein quantification by LC-MS/MS: Investigation of anticoagulant impact on assay performance and recommendations for best practices in method development.

Gao X, Chen C, Geng D, Bateman KP, Shi S, Woolf EJ, Xu Y. Gao X, et al. Among authors: xu y. J Pharm Biomed Anal. 2021 Mar 20;196:113895. doi: 10.1016/j.jpba.2021.113895. Epub 2021 Jan 11. J Pharm Biomed Anal. 2021. PMID: 33486450

7

Elimination of diastereomer interference to determine Telcagepant (MK-0974) in human plasma using on-line turbulent-flow technology and off-line solid-phase extraction coupled with liquid chromatography/tandem mass spectrometry.

Xu Y, Willson KJ, Anderson MD, Musson DG, Miller-Stein CM, Woolf EJ. Xu Y, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jun 1;877(16-17):1634-42. doi: 10.1016/j.jchromb.2009.04.006. Epub 2009 Apr 8. J Chromatogr B Analyt Technol Biomed Life Sci. 2009. PMID: 19398218

8

Hydrophilic interaction chromatography/tandem mass spectrometry for the simultaneous determination of three polar non-structurally related compounds, imipenem, cilastatin and an investigational beta-lactamase inhibitor, MK-4698, in biological matrices.

Xu Y, Xie W, Miller-Stein CM, Woolf EJ. Xu Y, et al. Rapid Commun Mass Spectrom. 2009 Jul;23(14):2195-205. doi: 10.1002/rcm.4138. Rapid Commun Mass Spectrom. 2009. PMID: 19530150

9

Immunoaffinity purification using anti-PEG antibody followed by two-dimensional liquid chromatography/tandem mass spectrometry for the quantification of a PEGylated therapeutic peptide in human plasma.

Xu Y, Mehl JT, Bakhtiar R, Woolf EJ. Xu Y, et al. Anal Chem. 2010 Aug 15;82(16):6877-86. doi: 10.1021/ac1009832. Anal Chem. 2010. PMID: 20704377

10

Evaluation of dried blood spot (DBS) technology versus plasma analysis for the determination of MK-1775 by HILIC-MS/MS in support of clinical studies.

Xu Y, Fang W, Zeng W, Leijen S, Woolf EJ. Xu Y, et al. Anal Bioanal Chem. 2012 Dec;404(10):3037-48. doi: 10.1007/s00216-012-6440-6. Epub 2012 Oct 26. Anal Bioanal Chem. 2012. PMID: 23099526

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