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Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders.
Martin M, Vermeiren S, Bostaille N, Eubelen M, Spitzer D, Vermeersch M, Profaci CP, Pozuelo E, Toussay X, Raman-Nair J, Tebabi P, America M, De Groote A, Sanderson LE, Cabochette P, Germano RFV, Torres D, Boutry S, de Kerchove d'Exaerde A, Bellefroid EJ, Phoenix TN, Devraj K, Lacoste B, Daneman R, Liebner S, Vanhollebeke B. Martin M, et al. Among authors: devraj k. Science. 2022 Feb 18;375(6582):eabm4459. doi: 10.1126/science.abm4459. Epub 2022 Feb 18. Science. 2022. PMID: 35175798
Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression.
Reis M, Czupalla CJ, Ziegler N, Devraj K, Zinke J, Seidel S, Heck R, Thom S, Macas J, Bockamp E, Fruttiger M, Taketo MM, Dimmeler S, Plate KH, Liebner S. Reis M, et al. Among authors: devraj k. J Exp Med. 2012 Aug 27;209(9):1611-27. doi: 10.1084/jem.20111580. Epub 2012 Aug 20. J Exp Med. 2012. PMID: 22908324 Free PMC article.
Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro.
Paolinelli R, Corada M, Ferrarini L, Devraj K, Artus C, Czupalla CJ, Rudini N, Maddaluno L, Papa E, Engelhardt B, Couraud PO, Liebner S, Dejana E. Paolinelli R, et al. Among authors: devraj k. PLoS One. 2013 Aug 5;8(8):e70233. doi: 10.1371/journal.pone.0070233. Print 2013. PLoS One. 2013. PMID: 23940549 Free PMC article.
In vitro models of the blood-brain barrier.
Czupalla CJ, Liebner S, Devraj K. Czupalla CJ, et al. Among authors: devraj k. Methods Mol Biol. 2014;1135:415-37. doi: 10.1007/978-1-4939-0320-7_34. Methods Mol Biol. 2014. PMID: 24510883
Nucleoside diphosphate kinase B regulates angiogenesis through modulation of vascular endothelial growth factor receptor type 2 and endothelial adherens junction proteins.
Feng Y, Gross S, Wolf NM, Butenschön VM, Qiu Y, Devraj K, Liebner S, Kroll J, Skolnik EY, Hammes HP, Wieland T. Feng Y, et al. Among authors: devraj k. Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2292-300. doi: 10.1161/ATVBAHA.114.304239. Epub 2014 Aug 21. Arterioscler Thromb Vasc Biol. 2014. PMID: 25147336
BACE-1 is expressed in the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer's disease.
Devraj K, Poznanovic S, Spahn C, Schwall G, Harter PN, Mittelbronn M, Antoniello K, Paganetti P, Muhs A, Heilemann M, Hawkins RA, Schrattenholz A, Liebner S. Devraj K, et al. J Cereb Blood Flow Metab. 2016 Jul;36(7):1281-94. doi: 10.1177/0271678X15606463. Epub 2015 Oct 13. J Cereb Blood Flow Metab. 2016. PMID: 26661166 Free PMC article.
Angiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling.
Gurnik S, Devraj K, Macas J, Yamaji M, Starke J, Scholz A, Sommer K, Di Tacchio M, Vutukuri R, Beck H, Mittelbronn M, Foerch C, Pfeilschifter W, Liebner S, Peters KG, Plate KH, Reiss Y. Gurnik S, et al. Among authors: devraj k. Acta Neuropathol. 2016 May;131(5):753-73. doi: 10.1007/s00401-016-1551-3. Epub 2016 Mar 1. Acta Neuropathol. 2016. PMID: 26932603 Free PMC article.
46 results