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Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders.
Martin M, Vermeiren S, Bostaille N, Eubelen M, Spitzer D, Vermeersch M, Profaci CP, Pozuelo E, Toussay X, Raman-Nair J, Tebabi P, America M, De Groote A, Sanderson LE, Cabochette P, Germano RFV, Torres D, Boutry S, de Kerchove d'Exaerde A, Bellefroid EJ, Phoenix TN, Devraj K, Lacoste B, Daneman R, Liebner S, Vanhollebeke B. Martin M, et al. Among authors: daneman r. Science. 2022 Feb 18;375(6582):eabm4459. doi: 10.1126/science.abm4459. Epub 2022 Feb 18. Science. 2022. PMID: 35175798
The blood-brain barrier.
Daneman R, Prat A. Daneman R, et al. Cold Spring Harb Perspect Biol. 2015 Jan 5;7(1):a020412. doi: 10.1101/cshperspect.a020412. Cold Spring Harb Perspect Biol. 2015. PMID: 25561720 Free PMC article. Review.
Neuronal Activity Regulates Blood-Brain Barrier Efflux Transport through Endothelial Circadian Genes.
Pulido RS, Munji RN, Chan TC, Quirk CR, Weiner GA, Weger BD, Rossi MJ, Elmsaouri S, Malfavon M, Deng A, Profaci CP, Blanchette M, Qian T, Foreman KL, Shusta EV, Gorman MR, Gachon F, Leutgeb S, Daneman R. Pulido RS, et al. Among authors: daneman r. Neuron. 2020 Dec 9;108(5):937-952.e7. doi: 10.1016/j.neuron.2020.09.002. Epub 2020 Sep 25. Neuron. 2020. PMID: 32979312 Free PMC article.
Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism.
Profaci CP, Harvey SS, Bajc K, Zhang TZ, Jeffrey DA, Zhang AZ, Nemec KM, Davtyan H, O'Brien CA, McKinsey GL, Longworth A, McMullen TP, Capocchi JK, Gonzalez JG, Lawson DA, Arnold TD, Davalos D, Blurton-Jones M, Dabertrand F, Bennett FC, Daneman R. Profaci CP, et al. Among authors: daneman r. Neuron. 2024 Sep 4;112(17):2910-2921.e7. doi: 10.1016/j.neuron.2024.07.015. Epub 2024 Aug 13. Neuron. 2024. PMID: 39142282 Free article.
71 results