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Metalloproteinase inhibition reduces AML growth, prevents stem cell loss, and improves chemotherapy effectiveness.
Pirillo C, Birch F, Tissot FS, Anton SG, Haltalli M, Tini V, Kong I, Piot C, Partridge B, Pospori C, Keeshan K, Santamaria S, Hawkins E, Falini B, Marra A, Duarte D, Lee CF, Roberts E, Lo Celso C. Pirillo C, et al. Among authors: santamaria s. Blood Adv. 2022 May 24;6(10):3126-3141. doi: 10.1182/bloodadvances.2021004321. Blood Adv. 2022. PMID: 35157757 Free PMC article.
Monoclonal antibodies against metzincin targets.
Santamaria S, de Groot R. Santamaria S, et al. Br J Pharmacol. 2019 Jan;176(1):52-66. doi: 10.1111/bph.14186. Epub 2018 Apr 2. Br J Pharmacol. 2019. PMID: 29488211 Free PMC article. Review.
Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide.
Santamaria S, Cuffaro D, Nuti E, Ciccone L, Tuccinardi T, Liva F, D'Andrea F, de Groot R, Rossello A, Ahnström J. Santamaria S, et al. Sci Rep. 2021 Jan 13;11(1):949. doi: 10.1038/s41598-020-80294-1. Sci Rep. 2021. PMID: 33441904 Free PMC article.
137 results