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Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance.
Nat Commun. 2022 Feb 8;13(1):735. doi: 10.1038/s41467-022-28039-8.
Nat Commun. 2022.
PMID: 35136059
Free PMC article.
Dynamic Ins2 Gene Activity Defines β-Cell Maturity States.
Chu CMJ, Modi H, Ellis C, Krentz NAJ, Skovsø S, Zhao YB, Cen H, Noursadeghi N, Panzhinskiy E, Hu X, Dionne DA, Xia YH, Xuan S, Huising MO, Kieffer TJ, Lynn FC, Johnson JD.
Chu CMJ, et al. Among authors: noursadeghi n.
Diabetes. 2022 Dec 1;71(12):2612-2631. doi: 10.2337/db21-1065.
Diabetes. 2022.
PMID: 36170671
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Human and mouse muscle transcriptomic analyses identify insulin receptor mRNA downregulation in hyperinsulinemia-associated insulin resistance.
Cen HH, Hussein B, Botezelli JD, Wang S, Zhang JA, Noursadeghi N, Jessen N, Rodrigues B, Timmons JA, Johnson JD.
Cen HH, et al. Among authors: noursadeghi n.
FASEB J. 2022 Jan;36(1):e22088. doi: 10.1096/fj.202100497RR.
FASEB J. 2022.
PMID: 34921686
Free PMC article.
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