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Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance.
Skovsø S, Panzhinskiy E, Kolic J, Cen HH, Dionne DA, Dai XQ, Sharma RB, Elghazi L, Ellis CE, Faulkner K, Marcil SAM, Overby P, Noursadeghi N, Hutchinson D, Hu X, Li H, Modi H, Wildi JS, Botezelli JD, Noh HL, Suk S, Gablaski B, Bautista A, Kim R, Cras-Méneur C, Flibotte S, Sinha S, Luciani DS, Nislow C, Rideout EJ, Cytrynbaum EN, Kim JK, Bernal-Mizrachi E, Alonso LC, MacDonald PE, Johnson JD. Skovsø S, et al. Among authors: hu x. Nat Commun. 2022 Feb 8;13(1):735. doi: 10.1038/s41467-022-28039-8. Nat Commun. 2022. PMID: 35136059 Free PMC article.
Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis.
Jeffrey KD, Alejandro EU, Luciani DS, Kalynyak TB, Hu X, Li H, Lin Y, Townsend RR, Polonsky KS, Johnson JD. Jeffrey KD, et al. Among authors: hu x. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8452-7. doi: 10.1073/pnas.0711232105. Epub 2008 Jun 11. Proc Natl Acad Sci U S A. 2008. PMID: 18550819 Free PMC article.
Bcl-2 and Bcl-xL suppress glucose signaling in pancreatic β-cells.
Luciani DS, White SA, Widenmaier SB, Saran VV, Taghizadeh F, Hu X, Allard MF, Johnson JD. Luciani DS, et al. Among authors: hu x. Diabetes. 2013 Jan;62(1):170-82. doi: 10.2337/db11-1464. Epub 2012 Aug 28. Diabetes. 2013. PMID: 22933114 Free PMC article.
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