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Proofreading of substrate structure by the Twin-Arginine Translocase is highly dependent on substrate conformational flexibility but surprisingly tolerant of surface charge and hydrophobicity changes.
Jones AS, Austerberry JI, Dajani R, Warwicker J, Curtis R, Derrick JP, Robinson C. Jones AS, et al. Among authors: dajani r. Biochim Biophys Acta. 2016 Dec;1863(12):3116-3124. doi: 10.1016/j.bbamcr.2016.09.006. Epub 2016 Sep 13. Biochim Biophys Acta. 2016. PMID: 27619192 Free article.
X-ray crystal structure of human dopamine sulfotransferase, SULT1A3. Molecular modeling and quantitative structure-activity relationship analysis demonstrate a molecular basis for sulfotransferase substrate specificity.
Dajani R, Cleasby A, Neu M, Wonacott AJ, Jhoti H, Hood AM, Modi S, Hersey A, Taskinen J, Cooke RM, Manchee GR, Coughtrie MW. Dajani R, et al. J Biol Chem. 1999 Dec 31;274(53):37862-8. doi: 10.1074/jbc.274.53.37862. J Biol Chem. 1999. PMID: 10608851 Free article.
142 results