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Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome.
Kim S, Bauernfeind F, Ablasser A, Hartmann G, Fitzgerald KA, Latz E, Hornung V. Kim S, et al. Among authors: latz e. Eur J Immunol. 2010 Jun;40(6):1545-51. doi: 10.1002/eji.201040425. Eur J Immunol. 2010. PMID: 20333626 Free PMC article.
NLRP3 inflammasomes link inflammation and metabolic disease.
De Nardo D, Latz E. De Nardo D, et al. Among authors: latz e. Trends Immunol. 2011 Aug;32(8):373-9. doi: 10.1016/j.it.2011.05.004. Epub 2011 Jul 4. Trends Immunol. 2011. PMID: 21733753 Free PMC article. Review.
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT. Heneka MT, et al. Among authors: latz e. Nature. 2013 Jan 31;493(7434):674-8. doi: 10.1038/nature11729. Epub 2012 Dec 19. Nature. 2013. PMID: 23254930 Free PMC article.
iGLuc: a luciferase-based inflammasome and protease activity reporter.
Bartok E, Bauernfeind F, Khaminets MG, Jakobs C, Monks B, Fitzgerald KA, Latz E, Hornung V. Bartok E, et al. Among authors: latz e. Nat Methods. 2013 Feb;10(2):147-154. doi: 10.1038/nmeth.2327. Epub 2013 Jan 6. Nat Methods. 2013. PMID: 23291722 Free PMC article.
Activation and regulation of the inflammasomes.
Latz E, Xiao TS, Stutz A. Latz E, et al. Nat Rev Immunol. 2013 Jun;13(6):397-411. doi: 10.1038/nri3452. Nat Rev Immunol. 2013. PMID: 23702978 Free PMC article. Review.
CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.
Sheedy FJ, Grebe A, Rayner KJ, Kalantari P, Ramkhelawon B, Carpenter SB, Becker CE, Ediriweera HN, Mullick AE, Golenbock DT, Stuart LM, Latz E, Fitzgerald KA, Moore KJ. Sheedy FJ, et al. Among authors: latz e. Nat Immunol. 2013 Aug;14(8):812-20. doi: 10.1038/ni.2639. Epub 2013 Jun 30. Nat Immunol. 2013. PMID: 23812099 Free PMC article.
The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.
Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenmüller W, Latz E. Franklin BS, et al. Among authors: latz e. Nat Immunol. 2014 Aug;15(8):727-37. doi: 10.1038/ni.2913. Epub 2014 Jun 22. Nat Immunol. 2014. PMID: 24952505 Free PMC article.
340 results