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Page 1
NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain.
Stutz A, Kolbe CC, Stahl R, Horvath GL, Franklin BS, van Ray O, Brinkschulte R, Geyer M, Meissner F, Latz E. Stutz A, et al. Among authors: brinkschulte r. J Exp Med. 2017 Jun 5;214(6):1725-1736. doi: 10.1084/jem.20160933. Epub 2017 May 2. J Exp Med. 2017. PMID: 28465465 Free PMC article.
Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease.
Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock DT, Geyer M, Walter J, Latz E, Heneka MT. Venegas C, et al. Among authors: brinkschulte r. Nature. 2017 Dec 20;552(7685):355-361. doi: 10.1038/nature25158. Nature. 2017. PMID: 29293211
Alternative splicing regulates stochastic NLRP3 activity.
Hoss F, Mueller JL, Rojas Ringeling F, Rodriguez-Alcazar JF, Brinkschulte R, Seifert G, Stahl R, Broderick L, Putnam CD, Kolodner RD, Canzar S, Geyer M, Hoffman HM, Latz E. Hoss F, et al. Among authors: brinkschulte r. Nat Commun. 2019 Jul 19;10(1):3238. doi: 10.1038/s41467-019-11076-1. Nat Commun. 2019. PMID: 31324763 Free PMC article.
β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia.
Friker LL, Scheiblich H, Hochheiser IV, Brinkschulte R, Riedel D, Latz E, Geyer M, Heneka MT. Friker LL, et al. Among authors: brinkschulte r. Cell Rep. 2020 Mar 17;30(11):3743-3754.e6. doi: 10.1016/j.celrep.2020.02.025. Cell Rep. 2020. PMID: 32187546 Free PMC article.
ATP-binding and hydrolysis of human NLRP3.
Brinkschulte R, Fußhöller DM, Hoss F, Rodríguez-Alcázar JF, Lauterbach MA, Kolbe CC, Rauen M, Ince S, Herrmann C, Latz E, Geyer M. Brinkschulte R, et al. Commun Biol. 2022 Nov 3;5(1):1176. doi: 10.1038/s42003-022-04120-2. Commun Biol. 2022. PMID: 36329210 Free PMC article.