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Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice.
Gu X, Richman J, Langfelder P, Wang N, Zhang S, Bañez-Coronel M, Wang HB, Yang L, Ramanathan L, Deng L, Park CS, Choi CR, Cantle JP, Gao F, Gray M, Coppola G, Bates GP, Ranum LPW, Horvath S, Colwell CS, Yang XW. Gu X, et al. Among authors: ramanathan l. Neuron. 2022 Apr 6;110(7):1173-1192.e7. doi: 10.1016/j.neuron.2022.01.006. Epub 2022 Feb 2. Neuron. 2022. PMID: 35114102 Free PMC article.
Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures.
Wang N, Langfelder P, Stricos M, Ramanathan L, Richman JB, Vaca R, Plascencia M, Gu X, Zhang S, Tamai TK, Zhang L, Gao F, Ouk K, Lu X, Ivanov LV, Vogt TF, Lu QR, Morton AJ, Colwell CS, Aaronson JS, Rosinski J, Horvath S, Yang XW. Wang N, et al. Among authors: ramanathan l. Neuron. 2022 Oct 19;110(20):3318-3338.e9. doi: 10.1016/j.neuron.2022.09.028. Neuron. 2022. PMID: 36265442 Free PMC article.
Reduced number of hypocretin neurons in human narcolepsy.
Thannickal TC, Moore RY, Nienhuis R, Ramanathan L, Gulyani S, Aldrich M, Cornford M, Siegel JM. Thannickal TC, et al. Among authors: ramanathan l. Neuron. 2000 Sep;27(3):469-74. doi: 10.1016/s0896-6273(00)00058-1. Neuron. 2000. PMID: 11055430 Free PMC article.
Greatly increased numbers of histamine cells in human narcolepsy with cataplexy.
John J, Thannickal TC, McGregor R, Ramanathan L, Ohtsu H, Nishino S, Sakai N, Yamanaka A, Stone C, Cornford M, Siegel JM. John J, et al. Among authors: ramanathan l. Ann Neurol. 2013 Dec;74(6):786-93. doi: 10.1002/ana.23968. Epub 2013 Sep 10. Ann Neurol. 2013. PMID: 23821583 Free PMC article.
Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy.
Thannickal TC, John J, Shan L, Swaab DF, Wu MF, Ramanathan L, McGregor R, Chew KT, Cornford M, Yamanaka A, Inutsuka A, Fronczek R, Lammers GJ, Worley PF, Siegel JM. Thannickal TC, et al. Among authors: ramanathan l. Sci Transl Med. 2018 Jun 27;10(447):eaao4953. doi: 10.1126/scitranslmed.aao4953. Sci Transl Med. 2018. PMID: 29950444 Free PMC article.
152 results