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Progression of Age-Related Macular Degeneration Among Individuals Homozygous for Risk Alleles on Chromosome 1 (CFH-CFHR5) or Chromosome 10 (ARMS2/HTRA1) or Both.
Schmitz-Valckenberg S, Fleckenstein M, Zouache MA, Pfau M, Pappas C, Hageman JL, Agrón E, Malley C, Keenan TDL, Chew EY, Hageman GS. Schmitz-Valckenberg S, et al. JAMA Ophthalmol. 2022 Mar 1;140(3):252-260. doi: 10.1001/jamaophthalmol.2021.6072. JAMA Ophthalmol. 2022. PMID: 35113155 Free PMC article.
Concordance of disease progression in bilateral geographic atrophy due to AMD.
Fleckenstein M, Adrion C, Schmitz-Valckenberg S, Göbel AP, Bindewald-Wittich A, Scholl HP, Mansmann U, Holz FG; FAM Study Group. Fleckenstein M, et al. Invest Ophthalmol Vis Sci. 2010 Feb;51(2):637-42. doi: 10.1167/iovs.09-3547. Epub 2009 Sep 24. Invest Ophthalmol Vis Sci. 2010. PMID: 19797219 Clinical Trial.
CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD.
Scholl HP, Fleckenstein M, Fritsche LG, Schmitz-Valckenberg S, Göbel A, Adrion C, Herold C, Keilhauer CN, Mackensen F, Mössner A, Pauleikhoff D, Weinberger AW, Mansmann U, Holz FG, Becker T, Weber BH. Scholl HP, et al. PLoS One. 2009 Oct 12;4(10):e7418. doi: 10.1371/journal.pone.0007418. PLoS One. 2009. PMID: 19823576 Free PMC article.
221 results