Tu J - Search Results

1

Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis.

Wen W, Cao H, Huang Y, Tu J, Wan C, Wan J, Han X, Chen H, Liu J, Rao L, Su C, Peng C, Sheng C, Ren Y. Wen W, et al. Among authors: tu j. J Med Chem. 2022 Feb 10;65(3):2656-2674. doi: 10.1021/acs.jmedchem.1c02102. Epub 2022 Jan 31. J Med Chem. 2022. PMID: 35099959

2

Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors.

Liu N, Zhong H, Tu J, Jiang Z, Jiang Y, Jiang Y, Jiang Y, Li J, Zhang W, Wang Y, Sheng C. Liu N, et al. Among authors: tu j. Eur J Med Chem. 2018 Jan 1;143:1510-1523. doi: 10.1016/j.ejmech.2017.10.043. Epub 2017 Oct 16. Eur J Med Chem. 2018. PMID: 29126739

3

Emerging New Targets for the Treatment of Resistant Fungal Infections.

Liu N, Tu J, Dong G, Wang Y, Sheng C. Liu N, et al. Among authors: tu j. J Med Chem. 2018 Jul 12;61(13):5484-5511. doi: 10.1021/acs.jmedchem.7b01413. Epub 2018 Jan 16. J Med Chem. 2018. PMID: 29294275 Review.

4

Novel non-peptidic small molecule inhibitors of secreted aspartic protease 2 (SAP2) for the treatment of resistant fungal infections.

Dong G, Liu Y, Wu Y, Tu J, Chen S, Liu N, Sheng C. Dong G, et al. Among authors: tu j. Chem Commun (Camb). 2018 Dec 14;54(96):13535-13538. doi: 10.1039/c8cc07810f. Epub 2018 Nov 15. Chem Commun (Camb). 2018. PMID: 30431632

5

Discovery of novel simplified isoxazole derivatives of sampangine as potent anti-cryptococcal agents.

Li Z, Liu N, Tu J, Ji C, Han G, Wang Y, Sheng C. Li Z, et al. Among authors: tu j. Bioorg Med Chem. 2019 Mar 1;27(5):832-840. doi: 10.1016/j.bmc.2019.01.029. Epub 2019 Jan 25. Bioorg Med Chem. 2019. PMID: 30711309

6

Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis.

Tu J, Li Z, Jiang Y, Ji C, Han G, Wang Y, Liu N, Sheng C. Tu J, et al. J Med Chem. 2019 Mar 14;62(5):2376-2389. doi: 10.1021/acs.jmedchem.8b01598. Epub 2019 Feb 22. J Med Chem. 2019. PMID: 30753074

7

Discovery of Simplified Sampangine Derivatives with Potent Antifungal Activities against Cryptococcal Meningitis.

Li Z, Liu N, Tu J, Ji C, Han G, Sheng C. Li Z, et al. Among authors: tu j. ACS Infect Dis. 2019 Aug 9;5(8):1376-1384. doi: 10.1021/acsinfecdis.9b00086. Epub 2019 May 22. ACS Infect Dis. 2019. PMID: 31070884

8

Drug Repurposing of Haloperidol: Discovery of New Benzocyclane Derivatives as Potent Antifungal Agents against Cryptococcosis and Candidiasis.

Ji C, Liu N, Tu J, Li Z, Han G, Li J, Sheng C. Ji C, et al. Among authors: tu j. ACS Infect Dis. 2020 May 8;6(5):768-786. doi: 10.1021/acsinfecdis.9b00197. Epub 2019 Oct 8. ACS Infect Dis. 2020. PMID: 31550886

9

Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis.

Han G, Liu N, Li C, Tu J, Li Z, Sheng C. Han G, et al. Among authors: tu j. J Med Chem. 2020 May 28;63(10):5341-5359. doi: 10.1021/acs.jmedchem.0c00102. Epub 2020 May 9. J Med Chem. 2020. PMID: 32347094

10

Targeting fungal virulence factor by small molecules: Structure-based discovery of novel secreted aspartic protease 2 (SAP2) inhibitors.

Li C, Liu Y, Wu S, Han G, Tu J, Dong G, Liu N, Sheng C. Li C, et al. Among authors: tu j. Eur J Med Chem. 2020 Sep 1;201:112515. doi: 10.1016/j.ejmech.2020.112515. Epub 2020 Jun 21. Eur J Med Chem. 2020. PMID: 32623209

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