Huang Y - Search Results

1

Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis.

Wen W, Cao H, Huang Y, Tu J, Wan C, Wan J, Han X, Chen H, Liu J, Rao L, Su C, Peng C, Sheng C, Ren Y. Wen W, et al. Among authors: huang y. J Med Chem. 2022 Feb 10;65(3):2656-2674. doi: 10.1021/acs.jmedchem.1c02102. Epub 2022 Jan 31. J Med Chem. 2022. PMID: 35099959

2

New insight into the binding modes of TNP-AMP to human liver fructose-1,6-bisphosphatase.

Han X, Huang Y, Zhang R, Xiao S, Zhu S, Qin N, Hong Z, Wei L, Feng J, Ren Y, Feng L, Wan J. Han X, et al. Among authors: huang y. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Aug 5;165:155-160. doi: 10.1016/j.saa.2016.04.002. Epub 2016 Apr 8. Spectrochim Acta A Mol Biomol Spectrosc. 2016. PMID: 27137358

3

In silico screening of a novel scaffold for fructose-1,6-bisphosatase (FBPase) inhibitors.

Huang Y, Chi B, Xu Y, Song R, Wei L, Rao L, Feng L, Ren Y, Wan J. Huang Y, et al. J Mol Graph Model. 2019 Jan;86:142-148. doi: 10.1016/j.jmgm.2018.10.017. Epub 2018 Oct 20. J Mol Graph Model. 2019. PMID: 30366190

4

Discovery of novel allosteric site and covalent inhibitors of FBPase with potent hypoglycemic effects.

Huang Y, Wei L, Han X, Chen H, Ren Y, Xu Y, Song R, Rao L, Su C, Peng C, Feng L, Wan J. Huang Y, et al. Eur J Med Chem. 2019 Dec 15;184:111749. doi: 10.1016/j.ejmech.2019.111749. Epub 2019 Sep 30. Eur J Med Chem. 2019. PMID: 31589992

5

Cov_FB3D: A De Novo Covalent Drug Design Protocol Integrating the BA-SAMP Strategy and Machine-Learning-Based Synthetic Tractability Evaluation.

Wei L, Wen W, Rao L, Huang Y, Lei M, Liu K, Hu S, Song R, Ren Y, Wan J. Wei L, et al. Among authors: huang y. J Chem Inf Model. 2020 Sep 28;60(9):4388-4402. doi: 10.1021/acs.jcim.9b01197. Epub 2020 Apr 9. J Chem Inf Model. 2020. PMID: 32233478

6

Identification of the New Covalent Allosteric Binding Site of Fructose-1,6-bisphosphatase with Disulfiram Derivatives toward Glucose Reduction.

Huang Y, Xu Y, Song R, Ni S, Liu J, Xu Y, Ren Y, Rao L, Wang Y, Wei L, Feng L, Su C, Peng C, Li J, Wan J. Huang Y, et al. J Med Chem. 2020 Jun 11;63(11):6238-6247. doi: 10.1021/acs.jmedchem.0c00699. Epub 2020 May 19. J Med Chem. 2020. PMID: 32375478

7

Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes.

Xu YX, Huang YY, Song RR, Ren YL, Chen X, Zhang C, Mao F, Li XK, Zhu J, Ni SS, Wan J, Li J. Xu YX, et al. Eur J Med Chem. 2020 Oct 1;203:112500. doi: 10.1016/j.ejmech.2020.112500. Epub 2020 Jul 15. Eur J Med Chem. 2020. PMID: 32711108

8

Biological evaluation and SAR analysis of novel covalent inhibitors against fructose-1,6-bisphosphatase.

Han X, Huang Y, Wei L, Chen H, Guo Y, Tang Z, Hu W, Xia Q, Wang Q, Yan J, Ren Y. Han X, et al. Among authors: huang y. Bioorg Med Chem. 2020 Sep 15;28(18):115624. doi: 10.1016/j.bmc.2020.115624. Epub 2020 Jul 10. Bioorg Med Chem. 2020. PMID: 32828433

9

Rapid Repurposing of Novel Combination Drugs for the Treatment of Heart Failure via a Computationally Guided Network Screening Approach.

Huang Y, Wang J, Liu J, Shi D, Li X, Wang M, Lu T, Jiang B, Xia C, Lin H, Xu Y, Li J. Huang Y, et al. J Chem Inf Model. 2022 Nov 14;62(21):5223-5232. doi: 10.1021/acs.jcim.1c00132. Epub 2021 Jun 20. J Chem Inf Model. 2022. PMID: 34151561

10

Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer's disease and depression.

Zhang C, Wang L, Xu Y, Huang Y, Huang J, Zhu J, Wang W, Li W, Sun A, Li X, Zhang H, Li J. Zhang C, et al. Among authors: huang j, huang y. Eur J Med Chem. 2022 Jun 5;236:114347. doi: 10.1016/j.ejmech.2022.114347. Epub 2022 Apr 6. Eur J Med Chem. 2022. PMID: 35430560

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