Chen H - Search Results

1

Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis.

Wen W, Cao H, Huang Y, Tu J, Wan C, Wan J, Han X, Chen H, Liu J, Rao L, Su C, Peng C, Sheng C, Ren Y. Wen W, et al. Among authors: chen h. J Med Chem. 2022 Feb 10;65(3):2656-2674. doi: 10.1021/acs.jmedchem.1c02102. Epub 2022 Jan 31. J Med Chem. 2022. PMID: 35099959

2

N-Acylamino Saccharin as an Emerging Cysteine-Directed Covalent Warhead and Its Application in the Identification of Novel FBPase Inhibitors toward Glucose Reduction.

Wen W, Cao H, Xu Y, Ren Y, Rao L, Shao X, Chen H, Wu L, Liu J, Su C, Peng C, Huang Y, Wan J. Wen W, et al. Among authors: chen h. J Med Chem. 2022 Jul 14;65(13):9126-9143. doi: 10.1021/acs.jmedchem.2c00336. Epub 2022 Jul 4. J Med Chem. 2022. PMID: 35786925

3

Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors.

Takrouri K, Chen T, Papadopoulos E, Sahoo R, Kabha E, Chen H, Cantel S, Wagner G, Halperin JA, Aktas BH, Chorev M. Takrouri K, et al. Among authors: chen t, chen h. Eur J Med Chem. 2014 Apr 22;77:361-77. doi: 10.1016/j.ejmech.2014.03.034. Epub 2014 Mar 13. Eur J Med Chem. 2014. PMID: 24675136 Free PMC article.

4

Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation.

Natarajan A, Guo Y, Harbinski F, Fan YH, Chen H, Luus L, Diercks J, Aktas H, Chorev M, Halperin JA. Natarajan A, et al. Among authors: chen h. J Med Chem. 2004 Oct 7;47(21):4979-82. doi: 10.1021/jm0496234. J Med Chem. 2004. PMID: 15456240

5

Access to (Z)-1,2-Endiamides and 1,1-Endiamides via a Base-Promoted Tandem Reaction.

Zhang Z, Fu B, Wang H, Chen H, Tu Y, Zhao J. Zhang Z, et al. Among authors: chen h. J Org Chem. 2020 Apr 17;85(8):5245-5254. doi: 10.1021/acs.joc.9b03305. Epub 2020 Apr 2. J Org Chem. 2020. PMID: 32207944

6

3,3-diaryl-1,3-dihydroindol-2-ones as antiproliferatives mediated by translation initiation inhibition.

Natarajan A, Fan YH, Chen H, Guo Y, Iyasere J, Harbinski F, Christ WJ, Aktas H, Halperin JA. Natarajan A, et al. Among authors: chen h. J Med Chem. 2004 Apr 8;47(8):1882-5. doi: 10.1021/jm0499716. J Med Chem. 2004. PMID: 15055987

7

Synthesis of new 2,4-Diaminopyrido[2,3-d]pyrimidine and 2,4-Diaminopyrrolo[2,3-d]pyrimidine inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase.

Rosowsky A, Chen H, Fu H, Queener SF. Rosowsky A, et al. Among authors: chen h. Bioorg Med Chem. 2003 Jan 2;11(1):59-67. doi: 10.1016/s0968-0896(02)00325-5. Bioorg Med Chem. 2003. PMID: 12467708

8

Synthesis and biological evaluation of thiazolidine-2,4-dione and 2,4-thione derivatives as inhibitors of translation initiation.

Chen H, Fan YH, Natarajan A, Guo Y, Iyasere J, Harbinski F, Luus L, Christ W, Aktas H, Halperin JA. Chen H, et al. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5401-5. doi: 10.1016/j.bmcl.2004.08.017. Bioorg Med Chem Lett. 2004. PMID: 15454234

9

Structure-activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium.

Fan YH, Chen H, Natarajan A, Guo Y, Harbinski F, Iyasere J, Christ W, Aktas H, Halperin JA. Fan YH, et al. Among authors: chen h. Bioorg Med Chem Lett. 2004 May 17;14(10):2547-50. doi: 10.1016/j.bmcl.2004.02.087. Bioorg Med Chem Lett. 2004. PMID: 15109648

10

Synthesis, characterization, and anticancer activities of the first platinum complexes from sucrose.

Sachinvala ND, Chen H, Niemczura WP, Furusawa E, Cramer RE, Rupp JJ, Ganjian I. Sachinvala ND, et al. Among authors: chen h. J Med Chem. 1993 Jun 11;36(12):1791-5. doi: 10.1021/jm00064a013. J Med Chem. 1993. PMID: 8510107 No abstract available.

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