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From proof of concept to the routine use of an automated and robust multi-dimensional liquid chromatography mass spectrometry workflow applied for the charge variant characterization of therapeutic antibodies.
Goyon A, Dai L, Chen T, Wei B, Yang F, Andersen N, Kopf R, Leiss M, Mølhøj M, Guillarme D, Stella C. Goyon A, et al. Among authors: yang f. J Chromatogr A. 2020 Mar 29;1615:460740. doi: 10.1016/j.chroma.2019.460740. Epub 2019 Nov 27. J Chromatogr A. 2020. PMID: 31796250
CD3 Target Affinity Chromatography Mass Spectrometry as a New Tool for Function-Structure Characterization of T-Cell Engaging Bispecific Antibody Proteoforms and Product-Related Variants.
Lippold S, Hook M, Spick C, Knaupp A, Whang K, Ruperti F, Cadang L, Andersen N, Vogt A, Grote M, Reusch D, Haberger M, Yang F, Schlothauer T. Lippold S, et al. Among authors: yang f. Anal Chem. 2023 Jan 31;95(4):2260-2268. doi: 10.1021/acs.analchem.2c03827. Epub 2023 Jan 13. Anal Chem. 2023. PMID: 36638115
Function-structure approach reveals novel insights on the interplay of Immunoglobulin G 1 proteoforms and Fc gamma receptor IIa allotypes.
Lippold S, Mistry K, Lenka S, Whang K, Liu P, Pitschi S, Kuhne F, Reusch D, Cadang L, Knaupp A, Izadi S, Dunkle A, Yang F, Schlothauer T. Lippold S, et al. Among authors: yang f. Front Immunol. 2023 Sep 18;14:1260446. doi: 10.3389/fimmu.2023.1260446. eCollection 2023. Front Immunol. 2023. PMID: 37790943 Free PMC article.
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