Newman A - Search Results

1

Pathogenic Mechanisms of Cytosolic and Membrane-Enriched α-Synuclein Converge on Fatty Acid Homeostasis.

Tripathi A, Alnakhala H, Terry-Kantor E, Newman A, Liu L, Imberdis T, Fanning S, Nuber S, Ramalingam N, Selkoe D, Dettmer U. Tripathi A, et al. Among authors: newman a. J Neurosci. 2022 Mar 9;42(10):2116-2130. doi: 10.1523/JNEUROSCI.1881-21.2022. Epub 2022 Jan 27. J Neurosci. 2022. PMID: 35086904 Free PMC article.

2

In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells.

Dettmer U, Newman AJ, Luth ES, Bartels T, Selkoe D. Dettmer U, et al. J Biol Chem. 2013 Mar 1;288(9):6371-85. doi: 10.1074/jbc.M112.403311. Epub 2013 Jan 14. J Biol Chem. 2013. PMID: 23319586 Free PMC article.

3

Defining the native state of α-synuclein.

Selkoe D, Dettmer U, Luth E, Kim N, Newman A, Bartels T. Selkoe D, et al. Among authors: newman a. Neurodegener Dis. 2014;13(2-3):114-7. doi: 10.1159/000355516. Epub 2013 Oct 30. Neurodegener Dis. 2014. PMID: 24192542 Review.

4

A new method for quantitative immunoblotting of endogenous α-synuclein.

Newman AJ, Selkoe D, Dettmer U. Newman AJ, et al. PLoS One. 2013 Nov 20;8(11):e81314. doi: 10.1371/journal.pone.0081314. eCollection 2013. PLoS One. 2013. PMID: 24278419 Free PMC article.

5

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.

Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Dettmer U, et al. Nat Commun. 2015 Jun 16;6:7314. doi: 10.1038/ncomms8314. Nat Commun. 2015. PMID: 26076669 Free PMC article.

6

KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity.

Dettmer U, Newman AJ, von Saucken VE, Bartels T, Selkoe D. Dettmer U, et al. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9596-601. doi: 10.1073/pnas.1505953112. Epub 2015 Jul 7. Proc Natl Acad Sci U S A. 2015. PMID: 26153422 Free PMC article.

7

Corrigendum: Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.

Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Dettmer U, et al. Nat Commun. 2015 Jul 30;6:8008. doi: 10.1038/ncomms9008. Nat Commun. 2015. PMID: 26224447 Free PMC article. No abstract available.

8

Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.

Dettmer U, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D. Dettmer U, et al. Among authors: newman aj. Hum Mol Genet. 2017 Sep 15;26(18):3466-3481. doi: 10.1093/hmg/ddx227. Hum Mol Genet. 2017. PMID: 28911198 Free PMC article.

9

Studying α-Synuclein Conformation by Intact-Cell Cross-Linking.

Imberdis T, Fanning S, Newman A, Ramalingam N, Dettmer U. Imberdis T, et al. Among authors: newman a. Methods Mol Biol. 2019;1948:77-91. doi: 10.1007/978-1-4939-9124-2_8. Methods Mol Biol. 2019. PMID: 30771172

10

Crowded organelles, lipid accumulation, and abnormal membrane tubulation in cellular models of enhanced α-synuclein membrane interaction.

Ericsson M, von Saucken V, Newman AJ, Doehr L, Hoesch C, Kim TE, Dettmer U. Ericsson M, et al. Brain Res. 2021 May 1;1758:147349. doi: 10.1016/j.brainres.2021.147349. Epub 2021 Feb 9. Brain Res. 2021. PMID: 33571519 Free PMC article.

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