Brea JM - Search Results

1

Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A₁ Antagonists.

Val C, Rodríguez-García C, Prieto-Díaz R, Crespo A, Azuaje J, Carbajales C, Majellaro M, Díaz-Holguín A, Brea JM, Loza MI, Gioé-Gallo C, Contino M, Stefanachi A, García-Mera X, Estévez JC, Gutiérrez-de-Terán H, Sotelo E. Val C, et al. Among authors: brea jm. J Med Chem. 2022 Feb 10;65(3):2091-2106. doi: 10.1021/acs.jmedchem.1c01636. Epub 2022 Jan 22. J Med Chem. 2022. PMID: 35068155 Free PMC article.

2

Butyrophenone analogues in the carbazole series as potential atypical antipsychotics: synthesis and determination of affinities at D(2), 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.

Masaguer CF, Raviña E, Fontenla JA, Brea J, Tristán H, Loza MI. Masaguer CF, et al. Eur J Med Chem. 2000 Jan;35(1):83-95. doi: 10.1016/s0223-5234(00)00109-4. Eur J Med Chem. 2000. PMID: 10733606

3

New serotonin 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptor antagonists: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo and heterocycloalkanones.

Brea J, Rodrigo J, Carrieri A, Sanz F, Cadavid MI, Enguix MJ, Villazón M, Mengod G, Caro Y, Masaguer CF, Raviña E, Centeno NB, Carotti A, Loza MI. Brea J, et al. J Med Chem. 2002 Jan 3;45(1):54-71. doi: 10.1021/jm011014y. J Med Chem. 2002. PMID: 11754579

4

Pyridazines. Part 28: 5-alkylidene-6-phenyl-3(2H)-pyridazinones, a new family of platelet aggregation inhibitors.

Sotelo E, Fraiz N, Yáñez M, Laguna R, Cano E, Brea J, Raviña E. Sotelo E, et al. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1575-7. doi: 10.1016/s0960-894x(02)00246-9. Bioorg Med Chem Lett. 2002. PMID: 12039565

5

New arylpiperazine derivatives with high affinity for alpha1A, D2 and 5-HT2A receptors.

González-Gómez JC, Santana L, Uriarte E, Brea J, Villazón M, Loza MI, De Luca M, Rivas ME, Montenegro GY, Fontenla JA. González-Gómez JC, et al. Bioorg Med Chem Lett. 2003 Jan 20;13(2):175-8. doi: 10.1016/s0960-894x(02)00933-2. Bioorg Med Chem Lett. 2003. PMID: 12482418

6

Conformationally constrained butyrophenones as new pharmacological tools to study 5-HT 2A and 5-HT 2C receptor behaviours.

Brea J, Masaguer CF, Villazón M, Cadavid MI, Raviña E, Fontaine F, Dezi C, Pastor M, Sanz F, Loza MI. Brea J, et al. Eur J Med Chem. 2003 Apr;38(4):433-40. doi: 10.1016/s0223-5234(03)00054-0. Eur J Med Chem. 2003. PMID: 12750032

7

Differential regulation of rat peripheral 5-HT(2A) and 5-HT(2B) receptor systems: influence of drug treatment.

Enguix MJ, Sánchez L, Villazón M, Brea J, Tristán H, Caruncho HJ, Cadavid MI, Loza MI. Enguix MJ, et al. Naunyn Schmiedebergs Arch Pharmacol. 2003 Aug;368(2):79-90. doi: 10.1007/s00210-003-0775-7. Epub 2003 Jul 12. Naunyn Schmiedebergs Arch Pharmacol. 2003. PMID: 12861437

8

Different pharmacological properties of two equipotent antagonists (clozapine and rauwolscine) for 5-HT2B receptors in rat stomach fundus.

Villazón M, Enguix MJ, Tristán H, Honrubia MA, Brea J, Maayani S, Cadavid MI, Loza MI. Villazón M, et al. Biochem Pharmacol. 2003 Sep 15;66(6):927-37. doi: 10.1016/s0006-2952(03)00426-x. Biochem Pharmacol. 2003. PMID: 12963479

9

Chemoenzymatic synthesis and binding affinity of novel (R)- and (S)-3-aminomethyl-1-tetralones, potential atypical antipsychotics.

Caro Y, Torrado M, Masaguer CF, Raviña E, Padín F, Brea J, Loza MI. Caro Y, et al. Bioorg Med Chem Lett. 2004 Feb 9;14(3):585-9. doi: 10.1016/j.bmcl.2003.11.064. Bioorg Med Chem Lett. 2004. PMID: 14741248

10

Synthesis and biological activity of new potential agonists for the human adenosine A2A receptor.

Bosch MP, Campos F, Niubó I, Rosell G, Díaz JL, Brea J, Loza MI, Guerrero A. Bosch MP, et al. J Med Chem. 2004 Jul 29;47(16):4041-53. doi: 10.1021/jm031143+. J Med Chem. 2004. PMID: 15267242

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