Zheng Z - Search Results

1

High-fidelity KKH variant of Staphylococcus aureus Cas9 nucleases with improved base mismatch discrimination.

Yuen CTL, Thean DGL, Chan BKC, Zhou P, Kwok CCS, Chu HY, Cheung MSH, Wang B, Chan YM, Mak SYL, Leung AY, Choi GCG, Zheng Z, Wong ASL. Yuen CTL, et al. Among authors: zheng z. Nucleic Acids Res. 2022 Feb 22;50(3):1650-1660. doi: 10.1093/nar/gkab1291. Nucleic Acids Res. 2022. PMID: 35051997 Free PMC article.

2

Engineered CRISPR-Cas9 nucleases with altered PAM specificities.

Kleinstiver BP, Prew MS, Tsai SQ, Topkar VV, Nguyen NT, Zheng Z, Gonzales AP, Li Z, Peterson RT, Yeh JR, Aryee MJ, Joung JK. Kleinstiver BP, et al. Among authors: zheng z. Nature. 2015 Jul 23;523(7561):481-5. doi: 10.1038/nature14592. Epub 2015 Jun 22. Nature. 2015. PMID: 26098369 Free PMC article.

3

High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects.

Kleinstiver BP, Pattanayak V, Prew MS, Tsai SQ, Nguyen NT, Zheng Z, Joung JK. Kleinstiver BP, et al. Among authors: zheng z. Nature. 2016 Jan 28;529(7587):490-5. doi: 10.1038/nature16526. Epub 2016 Jan 6. Nature. 2016. PMID: 26735016 Free PMC article.

4

Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9.

Choi GCG, Zhou P, Yuen CTL, Chan BKC, Xu F, Bao S, Chu HY, Thean D, Tan K, Wong KH, Zheng Z, Wong ASL. Choi GCG, et al. Among authors: zheng z. Nat Methods. 2019 Aug;16(8):722-730. doi: 10.1038/s41592-019-0473-0. Epub 2019 Jul 15. Nat Methods. 2019. PMID: 31308554

5

Publisher Correction: Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9.

Choi GCG, Zhou P, Yuen CTL, Chan BKC, Xu F, Bao S, Chu HY, Thean D, Tan K, Wong KH, Zheng Z, Wong ASL. Choi GCG, et al. Among authors: zheng z. Nat Methods. 2019 Aug;16(8):789. doi: 10.1038/s41592-019-0533-5. Nat Methods. 2019. PMID: 31337886

6

Rationally engineered Staphylococcus aureus Cas9 nucleases with high genome-wide specificity.

Tan Y, Chu AHY, Bao S, Hoang DA, Kebede FT, Xiong W, Ji M, Shi J, Zheng Z. Tan Y, et al. Among authors: zheng z. Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):20969-20976. doi: 10.1073/pnas.1906843116. Epub 2019 Sep 30. Proc Natl Acad Sci U S A. 2019. PMID: 31570596 Free PMC article.

7

A Three-Way Combinatorial CRISPR Screen for Analyzing Interactions among Druggable Targets.

Zhou P, Chan BKC, Wan YK, Yuen CTL, Choi GCG, Li X, Tong CSW, Zhong SSW, Sun J, Bao Y, Mak SYL, Chow MZY, Khaw JV, Leung SY, Zheng Z, Cheung LWT, Tan K, Wong KH, Chan HYE, Wong ASL. Zhou P, et al. Among authors: zheng z. Cell Rep. 2020 Aug 11;32(6):108020. doi: 10.1016/j.celrep.2020.108020. Cell Rep. 2020. PMID: 32783942 Free article.

8

Deep RNA Sequencing Revealed Fusion Junctional Heterogeneity May Predict Crizotinib Treatment Efficacy in ALK-Rearranged NSCLC.

Song Z, Lian S, Mak S, Chow MZ, Xu C, Wang W, Keung HY, Lu C, Kebede FT, Gao Y, Cheuk W, Cho WCS, Yang M, Zheng Z. Song Z, et al. Among authors: zheng z. J Thorac Oncol. 2022 Feb;17(2):264-276. doi: 10.1016/j.jtho.2021.09.016. Epub 2021 Oct 6. J Thorac Oncol. 2022. PMID: 34626839 Free article.

9

Machine learning-coupled combinatorial mutagenesis enables resource-efficient engineering of CRISPR-Cas9 genome editor activities.

Thean DGL, Chu HY, Fong JHC, Chan BKC, Zhou P, Kwok CCS, Chan YM, Mak SYL, Choi GCG, Ho JWK, Zheng Z, Wong ASL. Thean DGL, et al. Among authors: zheng z. Nat Commun. 2022 Apr 25;13(1):2219. doi: 10.1038/s41467-022-29874-5. Nat Commun. 2022. PMID: 35468907 Free PMC article.

10

Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition.

Kleinstiver BP, Prew MS, Tsai SQ, Nguyen NT, Topkar VV, Zheng Z, Joung JK. Kleinstiver BP, et al. Among authors: zheng z. Nat Biotechnol. 2015 Dec;33(12):1293-1298. doi: 10.1038/nbt.3404. Epub 2015 Nov 2. Nat Biotechnol. 2015. PMID: 26524662 Free PMC article.

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