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Structures of plasmepsin X from Plasmodium falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme.
Kesari P, Deshmukh A, Pahelkar N, Suryawanshi AB, Rathore I, Mishra V, Dupuis JH, Xiao H, Gustchina A, Abendroth J, Labaied M, Yada RY, Wlodawer A, Edwards TE, Lorimer DD, Bhaumik P. Kesari P, et al. Among authors: suryawanshi ab. Protein Sci. 2022 Apr;31(4):882-899. doi: 10.1002/pro.4279. Epub 2022 Feb 5. Protein Sci. 2022. PMID: 35048450 Free PMC article.