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RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state.
Belenguer G, Mastrogiovanni G, Pacini C, Hall Z, Dowbaj AM, Arnes-Benito R, Sljukic A, Prior N, Kakava S, Bradshaw CR, Davies S, Vacca M, Saeb-Parsy K, Koo BK, Huch M. Belenguer G, et al. Among authors: koo bk. Nat Commun. 2022 Jan 17;13(1):334. doi: 10.1038/s41467-021-27923-z. Nat Commun. 2022. PMID: 35039505 Free PMC article.
Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.
Broutier L, Mastrogiovanni G, Verstegen MM, Francies HE, Gavarró LM, Bradshaw CR, Allen GE, Arnes-Benito R, Sidorova O, Gaspersz MP, Georgakopoulos N, Koo BK, Dietmann S, Davies SE, Praseedom RK, Lieshout R, IJzermans JNM, Wigmore SJ, Saeb-Parsy K, Garnett MJ, van der Laan LJ, Huch M. Broutier L, et al. Among authors: koo bk. Nat Med. 2017 Dec;23(12):1424-1435. doi: 10.1038/nm.4438. Epub 2017 Nov 13. Nat Med. 2017. PMID: 29131160 Free PMC article.
Ub and Dub of RNF43/ZNRF3 in the WNT signalling pathway.
Colozza G, Koo BK. Colozza G, et al. Among authors: koo bk. EMBO Rep. 2021 May 5;22(5):e52970. doi: 10.15252/embr.202152970. Epub 2021 May 3. EMBO Rep. 2021. PMID: 33938624 Free PMC article.
Tracing oncogene-driven remodelling of the intestinal stem cell niche.
Yum MK, Han S, Fink J, Wu SS, Dabrowska C, Trendafilova T, Mustata R, Chatzeli L, Azzarelli R, Pshenichnaya I, Lee E, England F, Kim JK, Stange DE, Philpott A, Lee JH, Koo BK, Simons BD. Yum MK, et al. Among authors: koo bk. Nature. 2021 Jun;594(7863):442-447. doi: 10.1038/s41586-021-03605-0. Epub 2021 Jun 2. Nature. 2021. PMID: 34079126 Free PMC article.
945 results