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Page 1
Molecular mechanism of agonism and inverse agonism in ghrelin receptor.
Qin J, Cai Y, Xu Z, Ming Q, Ji SY, Wu C, Zhang H, Mao C, Shen DD, Hirata K, Ma Y, Yan W, Zhang Y, Shao Z. Qin J, et al. Among authors: hirata k. Nat Commun. 2022 Jan 13;13(1):300. doi: 10.1038/s41467-022-27975-9. Nat Commun. 2022. PMID: 35027551 Free PMC article.
Crystal structures of the human adiponectin receptors.
Tanabe H, Fujii Y, Okada-Iwabu M, Iwabu M, Nakamura Y, Hosaka T, Motoyama K, Ikeda M, Wakiyama M, Terada T, Ohsawa N, Hato M, Ogasawara S, Hino T, Murata T, Iwata S, Hirata K, Kawano Y, Yamamoto M, Kimura-Someya T, Shirouzu M, Yamauchi T, Kadowaki T, Yokoyama S. Tanabe H, et al. Among authors: hirata k. Nature. 2015 Apr 16;520(7547):312-316. doi: 10.1038/nature14301. Epub 2015 Apr 8. Nature. 2015. PMID: 25855295 Free PMC article.
Atomistic design of microbial opsin-based blue-shifted optogenetics tools.
Kato HE, Kamiya M, Sugo S, Ito J, Taniguchi R, Orito A, Hirata K, Inutsuka A, Yamanaka A, Maturana AD, Ishitani R, Sudo Y, Hayashi S, Nureki O. Kato HE, et al. Among authors: hirata k. Nat Commun. 2015 May 15;6:7177. doi: 10.1038/ncomms8177. Nat Commun. 2015. PMID: 25975962 Free PMC article.
Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6.
Taniguchi R, Inoue A, Sayama M, Uwamizu A, Yamashita K, Hirata K, Yoshida M, Tanaka Y, Kato HE, Nakada-Nakura Y, Otani Y, Nishizawa T, Doi T, Ohwada T, Ishitani R, Aoki J, Nureki O. Taniguchi R, et al. Among authors: hirata k. Nature. 2017 Aug 17;548(7667):356-360. doi: 10.1038/nature23448. Epub 2017 Aug 9. Nature. 2017. PMID: 28792932
Crystal structure of the endogenous agonist-bound prostanoid receptor EP3.
Morimoto K, Suno R, Hotta Y, Yamashita K, Hirata K, Yamamoto M, Narumiya S, Iwata S, Kobayashi T. Morimoto K, et al. Among authors: hirata k. Nat Chem Biol. 2019 Jan;15(1):8-10. doi: 10.1038/s41589-018-0171-8. Epub 2018 Dec 3. Nat Chem Biol. 2019. PMID: 30510192
An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor.
Liu X, Kaindl J, Korczynska M, Stößel A, Dengler D, Stanek M, Hübner H, Clark MJ, Mahoney J, Matt RA, Xu X, Hirata K, Shoichet BK, Sunahara RK, Kobilka BK, Gmeiner P. Liu X, et al. Among authors: hirata k. Nat Chem Biol. 2020 Jul;16(7):749-755. doi: 10.1038/s41589-020-0549-2. Epub 2020 Jun 1. Nat Chem Biol. 2020. PMID: 32483378 Free PMC article.
4,352 results