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Harnessing the anti-cancer natural product nimbolide for targeted protein degradation.
Spradlin JN, Hu X, Ward CC, Brittain SM, Jones MD, Ou L, To M, Proudfoot A, Ornelas E, Woldegiorgis M, Olzmann JA, Bussiere DE, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Maimone TJ, Nomura DK. Spradlin JN, et al. Among authors: nomura dk. Nat Chem Biol. 2019 Jul;15(7):747-755. doi: 10.1038/s41589-019-0304-8. Epub 2019 Jun 17. Nat Chem Biol. 2019. PMID: 31209351 Free PMC article.
Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells.
Coles GL, Cristea S, Webber JT, Levin RS, Moss SM, He A, Sangodkar J, Hwang YC, Arand J, Drainas AP, Mooney NA, Demeter J, Spradlin JN, Mauch B, Le V, Shue YT, Ko JH, Lee MC, Kong C, Nomura DK, Ohlmeyer M, Swaney DL, Krogan NJ, Jackson PK, Narla G, Gordan JD, Shokat KM, Sage J. Coles GL, et al. Among authors: nomura dk. Cancer Cell. 2020 Jul 13;38(1):129-143.e7. doi: 10.1016/j.ccell.2020.05.003. Epub 2020 Jun 11. Cancer Cell. 2020. PMID: 32531271 Free PMC article.
A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL.
Tong B, Spradlin JN, Novaes LFT, Zhang E, Hu X, Moeller M, Brittain SM, McGregor LM, McKenna JM, Tallarico JA, Schirle M, Maimone TJ, Nomura DK. Tong B, et al. Among authors: nomura dk. ACS Chem Biol. 2020 Jul 17;15(7):1788-1794. doi: 10.1021/acschembio.0c00348. Epub 2020 Jun 25. ACS Chem Biol. 2020. PMID: 32568522 Free PMC article.
Manumycin polyketides act as molecular glues between UBR7 and P53.
Isobe Y, Okumura M, McGregor LM, Brittain SM, Jones MD, Liang X, White R, Forrester W, McKenna JM, Tallarico JA, Schirle M, Maimone TJ, Nomura DK. Isobe Y, et al. Among authors: nomura dk. Nat Chem Biol. 2020 Nov;16(11):1189-1198. doi: 10.1038/s41589-020-0557-2. Epub 2020 Jun 22. Nat Chem Biol. 2020. PMID: 32572277 Free PMC article.
183 results