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High-throughput and high-content bioassay enables tuning of polyester nanoparticles for cellular uptake, endosomal escape, and systemic in vivo delivery of mRNA.
Sci Adv. 2022 Jan 7;8(1):eabk2855. doi: 10.1126/sciadv.abk2855. Epub 2022 Jan 5.
Sci Adv. 2022.
PMID: 34985952
Free PMC article.
Poly(Beta-Amino Ester) Nanoparticles Enable Nonviral Delivery of CRISPR-Cas9 Plasmids for Gene Knockout and Gene Deletion.
Rui Y, Varanasi M, Mendes S, Yamagata HM, Wilson DR, Green JJ.
Rui Y, et al. Among authors: yamagata hm.
Mol Ther Nucleic Acids. 2020 Jun 5;20:661-672. doi: 10.1016/j.omtn.2020.04.005. Epub 2020 Apr 21.
Mol Ther Nucleic Acids. 2020.
PMID: 32380416
Free PMC article.
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Machine learning guided structure function predictions enable in silico nanoparticle screening for polymeric gene delivery.
Gong D, Ben-Akiva E, Singh A, Yamagata H, Est-Witte S, Shade JK, Trayanova NA, Green JJ.
Gong D, et al.
Acta Biomater. 2022 Dec;154:349-358. doi: 10.1016/j.actbio.2022.09.072. Epub 2022 Oct 4.
Acta Biomater. 2022.
PMID: 36206976
Free PMC article.
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