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PI-88 and Related Heparan Sulfate Mimetics.
Chhabra M, Ferro V. Chhabra M, et al. Adv Exp Med Biol. 2020;1221:473-491. doi: 10.1007/978-3-030-34521-1_19. Adv Exp Med Biol. 2020. PMID: 32274723 Review.
Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction.
Guimond SE, Mycroft-West CJ, Gandhi NS, Tree JA, Le TT, Spalluto CM, Humbert MV, Buttigieg KR, Coombes N, Elmore MJ, Wand M, Nyström K, Said J, Setoh YX, Amarilla AA, Modhiran N, Sng JDJ, Chhabra M, Young PR, Rawle DJ, Lima MA, Yates EA, Karlsson R, Miller RL, Chen YH, Bagdonaite I, Yang Z, Stewart J, Nguyen D, Laidlaw S, Hammond E, Dredge K, Wilkinson TMA, Watterson D, Khromykh AA, Suhrbier A, Carroll MW, Trybala E, Bergström T, Ferro V, Skidmore MA, Turnbull JE. Guimond SE, et al. Among authors: chhabra m. ACS Cent Sci. 2022 May 25;8(5):527-545. doi: 10.1021/acscentsci.1c01293. Epub 2022 Mar 29. ACS Cent Sci. 2022. PMID: 35647275 Free PMC article.
SARS-CoV-2 triggers complement activation through interactions with heparan sulfate.
Lo MW, Amarilla AA, Lee JD, Albornoz EA, Modhiran N, Clark RJ, Ferro V, Chhabra M, Khromykh AA, Watterson D, Woodruff TM. Lo MW, et al. Among authors: chhabra m. Clin Transl Immunology. 2022 Aug 18;11(8):e1413. doi: 10.1002/cti2.1413. eCollection 2022. Clin Transl Immunology. 2022. PMID: 35999893 Free PMC article.
Amphiphilic Heparinoids as Potent Antiviral Agents against SARS-CoV-2.
Chhabra M, Shanthamurthy CD, Kumar NV, Mardhekar S, Vishweshwara SS, Wimmer N, Modhiran N, Watterson D, Amarilla AA, Cha JS, Beckett JR, De Voss JJ, Kayal Y, Vlodavsky I, Dorsett LR, Smith RAA, Gandhi NS, Kikkeri R, Ferro V. Chhabra M, et al. J Med Chem. 2024 Jul 25;67(14):11885-11916. doi: 10.1021/acs.jmedchem.4c00487. Epub 2024 Jul 12. J Med Chem. 2024. PMID: 38995734
Abiraterone acetate in the treatment of prostate cancer.
Thakur A, Roy A, Ghosh A, Chhabra M, Banerjee S. Thakur A, et al. Among authors: chhabra m. Biomed Pharmacother. 2018 May;101:211-218. doi: 10.1016/j.biopha.2018.02.067. Epub 2018 Feb 26. Biomed Pharmacother. 2018. PMID: 29494958 Review.
265 results