Kümmel D - Search Results

1

Structural analysis revealed a novel conformation of the NTRC reductase domain from Chlamydomonas reinhardtii.

Marchetti GM, Füsser F, Singh RK, Brummel M, Koch O, Kümmel D, Hippler M. Marchetti GM, et al. Among authors: kummel d. J Struct Biol. 2022 Mar;214(1):107829. doi: 10.1016/j.jsb.2021.107829. Epub 2021 Dec 30. J Struct Biol. 2022. PMID: 34974142

2

Biochemical and Structural Characterization of an Unusual and Naturally Split Class 3 Intein.

Hoffmann S, Terhorst TME, Singh RK, Kümmel D, Pietrokovski S, Mootz HD. Hoffmann S, et al. Among authors: kummel d. Chembiochem. 2021 Jan 15;22(2):364-373. doi: 10.1002/cbic.202000509. Epub 2020 Sep 30. Chembiochem. 2021. PMID: 32813312 Free PMC article.

3

Engineered SAM Synthetases for Enzymatic Generation of AdoMet Analogs with Photocaging Groups and Reversible DNA Modification in Cascade Reactions.

Michailidou F, Klöcker N, Cornelissen NV, Singh RK, Peters A, Ovcharenko A, Kümmel D, Rentmeister A. Michailidou F, et al. Among authors: kummel d. Angew Chem Int Ed Engl. 2021 Jan 4;60(1):480-485. doi: 10.1002/anie.202012623. Epub 2020 Nov 13. Angew Chem Int Ed Engl. 2021. PMID: 33017502 Free PMC article.

4

Novel starting points for fragment-based drug design against mycobacterial thioredoxin reductase identified using crystallographic fragment screening.

Füsser FT, Wollenhaupt J, Weiss MS, Kümmel D, Koch O. Füsser FT, et al. Among authors: kummel d. Acta Crystallogr D Struct Biol. 2023 Sep 1;79(Pt 9):857-865. doi: 10.1107/S2059798323005223. Epub 2023 Aug 14. Acta Crystallogr D Struct Biol. 2023. PMID: 37574972 Free PMC article.

5

Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer.

Escobar-Hoyos LF, Penson A, Kannan R, Cho H, Pan CH, Singh RK, Apken LH, Hobbs GA, Luo R, Lecomte N, Babu S, Pan FC, Alonso-Curbelo D, Morris JP 4th, Askan G, Grbovic-Huezo O, Ogrodowski P, Bermeo J, Saglimbeni J, Cruz CD, Ho YJ, Lawrence SA, Melchor JP, Goda GA, Bai K, Pastore A, Hogg SJ, Raghavan S, Bailey P, Chang DK, Biankin A, Shroyer KR, Wolpin BM, Aguirre AJ, Ventura A, Taylor B, Der CJ, Dominguez D, Kümmel D, Oeckinghaus A, Lowe SW, Bradley RK, Abdel-Wahab O, Leach SD. Escobar-Hoyos LF, et al. Among authors: kummel d. Cancer Cell. 2020 Aug 10;38(2):198-211.e8. doi: 10.1016/j.ccell.2020.05.010. Epub 2020 Jun 18. Cancer Cell. 2020. PMID: 32559497 Free PMC article.

6

Structure of reverse gyrase with a minimal latch that supports ATP-dependent positive supercoiling without specific interactions with the topoisomerase domain.

Mhaindarkar VP, Rasche R, Kümmel D, Rudolph MG, Klostermeier D. Mhaindarkar VP, et al. Among authors: kummel d. Acta Crystallogr D Struct Biol. 2023 Jun 1;79(Pt 6):498-507. doi: 10.1107/S2059798323002565. Epub 2023 May 19. Acta Crystallogr D Struct Biol. 2023. PMID: 37204816 Free PMC article.

7

Structural and biochemical analysis of a novel atypically split intein reveals a conserved histidine specific to cysteine-less inteins.

Pasch T, Schröder A, Kattelmann S, Eisenstein M, Pietrokovski S, Kümmel D, Mootz HD. Pasch T, et al. Among authors: kummel d. Chem Sci. 2023 Apr 24;14(19):5204-5213. doi: 10.1039/d3sc01200j. eCollection 2023 May 17. Chem Sci. 2023. PMID: 37206380 Free PMC article.

8

Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis.

Zech R, Kiontke S, Mueller U, Oeckinghaus A, Kümmel D. Zech R, et al. Among authors: kummel d. J Biol Chem. 2016 Sep 16;291(38):20008-20. doi: 10.1074/jbc.M116.732446. Epub 2016 Aug 4. J Biol Chem. 2016. PMID: 27493206 Free PMC article.

9

TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation.

Fitzian K, Brückner A, Brohée L, Zech R, Antoni C, Kiontke S, Gasper R, Linard Matos AL, Beel S, Wilhelm S, Gerke V, Ungermann C, Nellist M, Raunser S, Demetriades C, Oeckinghaus A, Kümmel D. Fitzian K, et al. Among authors: kummel d. Mol Cell. 2021 Jul 1;81(13):2705-2721.e8. doi: 10.1016/j.molcel.2021.04.019. Epub 2021 May 10. Mol Cell. 2021. PMID: 33974911 Free article.

10

Structure of D-63 from sulfolobus spindle-shaped virus 1: surface properties of the dimeric four-helix bundle suggest an adaptor protein function.

Kraft P, Kümmel D, Oeckinghaus A, Gauss GH, Wiedenheft B, Young M, Lawrence CM. Kraft P, et al. Among authors: kummel d. J Virol. 2004 Jul;78(14):7438-42. doi: 10.1128/JVI.78.14.7438-7442.2004. J Virol. 2004. PMID: 15220417 Free PMC article.

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