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The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in β-tubulin.
Yang J, Yan W, Yu Y, Wang Y, Yang T, Xue L, Yuan X, Long C, Liu Z, Chen X, Hu M, Zheng L, Qiu Q, Pei H, Li D, Wang F, Bai P, Wen J, Ye H, Chen L. Yang J, et al. Among authors: yuan x. J Biol Chem. 2018 Jun 15;293(24):9461-9472. doi: 10.1074/jbc.RA117.001658. Epub 2018 Apr 24. J Biol Chem. 2018. PMID: 29691282 Free PMC article.
Identification of Pyrrolo[2,3- d]pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia.
Yuan X, Chen Y, Zhang W, He J, Lei L, Tang M, Liu J, Li M, Dou C, Yang T, Yang L, Yang S, Wei Y, Peng A, Niu T, Xiang M, Ye H, Chen L. Yuan X, et al. J Med Chem. 2019 Apr 25;62(8):4158-4173. doi: 10.1021/acs.jmedchem.9b00223. Epub 2019 Apr 15. J Med Chem. 2019. PMID: 30939008
Correction to "Discovery of Potent and Orally Effective Dual Janus Kinase 2/FLT3 Inhibitors for the Treatment of Acute Myelogenous Leukemia and Myeloproliferative Neoplasms".
Yang T, Hu M, Qi W, Yang Z, Tang M, He J, Chen Y, Bai P, Yuan X, Zhang C, Liu K, Lu Y, Xiang M, Chen L. Yang T, et al. Among authors: yuan x. J Med Chem. 2020 Feb 13;63(3):1441-1442. doi: 10.1021/acs.jmedchem.0c00025. Epub 2020 Jan 27. J Med Chem. 2020. PMID: 31985218 No abstract available.
Correction to "N-(Pyrimidin-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-amine Derivatives as Selective Janus Kinase 2 Inhibitors for the Treatment of Myeloproliferative Neoplasms".
Yang T, Hu M, Chen Y, Xiang M, Tang M, Qi W, Shi M, He J, Yuan X, Zhang C, Liu K, Li J, Yang Z, Chen L. Yang T, et al. Among authors: yuan x. J Med Chem. 2021 Feb 25;64(4):2310. doi: 10.1021/acs.jmedchem.1c00198. Epub 2021 Feb 16. J Med Chem. 2021. PMID: 33591746 No abstract available.
Discovery, Optimization, and Evaluation of Quinazolinone Derivatives with Novel Linkers as Orally Efficacious Phosphoinositide-3-Kinase Delta Inhibitors for Treatment of Inflammatory Diseases.
Liu K, Li D, Zheng W, Shi M, Chen Y, Tang M, Yang T, Zhao M, Deng D, Zhang C, Liu J, Yuan X, Yang Z, Chen L. Liu K, et al. Among authors: yuan x. J Med Chem. 2021 Jul 8;64(13):8951-8970. doi: 10.1021/acs.jmedchem.1c00004. Epub 2021 Jun 17. J Med Chem. 2021. PMID: 34138567
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