Sajan MP - Search Results

1

Control of β-Site Amyloid Precursor Protein-Cleaving Enzyme-1 Expression by Protein Kinase C-λ/ι and Nuclear Factor κ-B.

Sajan MP, Leitges M, Park C, Diamond DM, Wu J, Hansen BC, Duncan MA, Apostolatos CA, Apostolatos AH, Kindy M, Farese RV. Sajan MP, et al. Curr Alzheimer Res. 2021;18(12):941-955. doi: 10.2174/1567205019666211222120448. Curr Alzheimer Res. 2021. PMID: 34951366

2

Atypical protein kinase C in cardiometabolic abnormalities.

Farese RV, Sajan MP. Farese RV, et al. Among authors: sajan mp. Curr Opin Lipidol. 2012 Jun;23(3):175-181. doi: 10.1097/MOL.0b013e328352c4c7. Curr Opin Lipidol. 2012. PMID: 22449812 Free PMC article. Review.

3

Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ_1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease.

Sajan MP, Hansen BC, Higgs MG, Kahn CR, Braun U, Leitges M, Park CR, Diamond DM, Farese RV. Sajan MP, et al. Neurobiol Aging. 2018 Jan;61:225-237. doi: 10.1016/j.neurobiolaging.2017.09.001. Epub 2017 Sep 15. Neurobiol Aging. 2018. PMID: 29032894 Free PMC article.

4

Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1-40/42 and Phospho-Tau May Abet Alzheimer Development.

Sajan M, Hansen B, Ivey R 3rd, Sajan J, Ari C, Song S, Braun U, Leitges M, Farese-Higgs M, Farese RV. Sajan M, et al. Diabetes. 2016 Jul;65(7):1892-903. doi: 10.2337/db15-1428. Epub 2016 Feb 19. Diabetes. 2016. PMID: 26895791 Free PMC article.

5

Skeletal muscle insulin resistance in obesity-associated type 2 diabetes in monkeys is linked to a defect in insulin activation of protein kinase C-zeta/lambda/iota.

Standaert ML, Ortmeyer HK, Sajan MP, Kanoh Y, Bandyopadhyay G, Hansen BC, Farese RV. Standaert ML, et al. Among authors: sajan mp. Diabetes. 2002 Oct;51(10):2936-43. doi: 10.2337/diabetes.51.10.2936. Diabetes. 2002. PMID: 12351430

6

Defective activation of atypical protein kinase C zeta and lambda by insulin and phosphatidylinositol-3,4,5-(PO4)(3) in skeletal muscle of rats following high-fat feeding and streptozotocin-induced diabetes.

Kanoh Y, Sajan MP, Bandyopadhyay G, Miura A, Standaert ML, Farese RV. Kanoh Y, et al. Among authors: sajan mp. Endocrinology. 2003 Mar;144(3):947-54. doi: 10.1210/en.2002-221017. Endocrinology. 2003. PMID: 12586772

7

Tissue-specific differences in activation of atypical protein kinase C and protein kinase B in muscle, liver, and adipocytes of insulin receptor substrate-1 knockout mice.

Sajan MP, Standaert ML, Miura A, Kahn CR, Farese RV. Sajan MP, et al. Mol Endocrinol. 2004 Oct;18(10):2513-21. doi: 10.1210/me.2004-0045. Epub 2004 Jul 15. Mol Endocrinol. 2004. PMID: 15256535

8

Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/Akt): actions and defects in obesity and type II diabetes.

Farese RV, Sajan MP, Standaert ML. Farese RV, et al. Among authors: sajan mp. Exp Biol Med (Maywood). 2005 Oct;230(9):593-605. doi: 10.1177/153537020523000901. Exp Biol Med (Maywood). 2005. PMID: 16179727 Review.

9

The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity.

Sajan MP, Standaert ML, Nimal S, Varanasi U, Pastoor T, Mastorides S, Braun U, Leitges M, Farese RV. Sajan MP, et al. J Lipid Res. 2009 Jun;50(6):1133-45. doi: 10.1194/jlr.M800520-JLR200. Epub 2009 Feb 6. J Lipid Res. 2009. PMID: 19202134 Free PMC article.

10

Metabolic functions of atypical protein kinase C: "good" and "bad" as defined by nutritional status.

Farese RV, Sajan MP. Farese RV, et al. Among authors: sajan mp. Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E385-94. doi: 10.1152/ajpendo.00608.2009. Epub 2009 Dec 8. Am J Physiol Endocrinol Metab. 2010. PMID: 19996389 Free PMC article. Review.

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