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Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions.
Prox J, Bernreuther C, Altmeppen H, Grendel J, Glatzel M, D'Hooge R, Stroobants S, Ahmed T, Balschun D, Willem M, Lammich S, Isbrandt D, Schweizer M, Horré K, De Strooper B, Saftig P. Prox J, et al. Among authors: grendel j. J Neurosci. 2013 Aug 7;33(32):12915-28, 12928a. doi: 10.1523/JNEUROSCI.5910-12.2013. J Neurosci. 2013. PMID: 23926248 Free PMC article.
Arc/Arg3.1 mediates a critical period for spatial learning and hippocampal networks.
Gao X, Castro-Gomez S, Grendel J, Graf S, Süsens U, Binkle L, Mensching D, Isbrandt D, Kuhl D, Ohana O. Gao X, et al. Among authors: grendel j. Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):12531-12536. doi: 10.1073/pnas.1810125115. Epub 2018 Nov 15. Proc Natl Acad Sci U S A. 2018. PMID: 30442670 Free PMC article.