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165 results

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Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design.
Yeh TK, Song JS, Chang PW, Yu JC, Chang CH, Liao FY, Tien YW, Kuppusamy R, Li AS, Chen CH, Chen CW, Lin LM, Chang HH, Huang CH, Yao JY, Wu MH, Peng YH, Hsueh CC, Hsiao WC, Chen PH, Lin CY, Hsieh SH, Shih C, Hung MS, Wu SY, Kuo CC, Ueng SH. Yeh TK, et al. Eur J Med Chem. 2022 Feb 5;229:114043. doi: 10.1016/j.ejmech.2021.114043. Epub 2021 Dec 8. Eur J Med Chem. 2022. PMID: 34929581
Quantitative determination of salidroside in rat plasma by on-line solid-phase extraction integrated with high-performance liquid chromatography/electrospray ionization tandem mass spectrometry.
Chang YW, Yao HT, Hsieh SH, Lu TJ, Yeh TK. Chang YW, et al. Among authors: yeh tk. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Sep 15;857(1):164-9. doi: 10.1016/j.jchromb.2007.06.029. Epub 2007 Jul 1. J Chromatogr B Analyt Technol Biomed Life Sci. 2007. PMID: 17631426
Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors.
Tsai TY, Hsu T, Chen CT, Cheng JH, Yeh TK, Chen X, Huang CY, Chang CN, Yeh KC, Hsieh SH, Chien CH, Chang YW, Huang CH, Huang YW, Huang CL, Wu SH, Wang MH, Lu CT, Chao YS, Jiaang WT. Tsai TY, et al. Among authors: yeh tk, yeh kc. Bioorg Med Chem. 2009 Mar 15;17(6):2388-99. doi: 10.1016/j.bmc.2009.02.020. Epub 2009 Feb 20. Bioorg Med Chem. 2009. PMID: 19261480
Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice.
Wu CH, Hung MS, Song JS, Yeh TK, Chou MC, Chu CM, Jan JJ, Hsieh MT, Tseng SL, Chang CP, Hsieh WP, Lin Y, Yeh YN, Chung WL, Kuo CW, Lin CY, Shy HS, Chao YS, Shia KS. Wu CH, et al. Among authors: yeh yn, yeh tk. J Med Chem. 2009 Jul 23;52(14):4496-510. doi: 10.1021/jm900471u. J Med Chem. 2009. PMID: 19530697
Synthesis and evaluation of 3-aroylindoles as anticancer agents: metabolite approach.
Wu YS, Coumar MS, Chang JY, Sun HY, Kuo FM, Kuo CC, Chen YJ, Chang CY, Hsiao CL, Liou JP, Chen CP, Yao HT, Chiang YK, Tan UK, Chen CT, Chu CY, Wu SY, Yeh TK, Lin CY, Hsieh HP. Wu YS, et al. Among authors: yeh tk. J Med Chem. 2009 Aug 13;52(15):4941-5. doi: 10.1021/jm900060s. J Med Chem. 2009. PMID: 19586033
(2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.
Yeh TK, Tsai TY, Hsu T, Cheng JH, Chen X, Song JS, Shy HS, Chiou MC, Chien CH, Tseng YJ, Huang CY, Yeh KC, Huang YL, Huang CH, Huang YW, Wang MH, Tang HK, Chao YS, Chen CT, Jiaang WT. Yeh TK, et al. Among authors: yeh kc. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3596-600. doi: 10.1016/j.bmcl.2010.04.124. Epub 2010 May 17. Bioorg Med Chem Lett. 2010. PMID: 20483603
165 results