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Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design.
Yeh TK, Song JS, Chang PW, Yu JC, Chang CH, Liao FY, Tien YW, Kuppusamy R, Li AS, Chen CH, Chen CW, Lin LM, Chang HH, Huang CH, Yao JY, Wu MH, Peng YH, Hsueh CC, Hsiao WC, Chen PH, Lin CY, Hsieh SH, Shih C, Hung MS, Wu SY, Kuo CC, Ueng SH. Yeh TK, et al. Among authors: chang hh, chang pw, chang ch. Eur J Med Chem. 2022 Feb 5;229:114043. doi: 10.1016/j.ejmech.2021.114043. Epub 2021 Dec 8. Eur J Med Chem. 2022. PMID: 34929581
Novel Nrf2/ARE activator, trans-Coniferylaldehyde, induces a HO-1-mediated defense mechanism through a dual p38α/MAPKAPK-2 and PK-N3 signaling pathway.
Chen HH, Wang TC, Lee YC, Shen PT, Chang JY, Yeh TK, Huang CH, Chang HH, Cheng SY, Lin CY, Shih C, Chen CT, Liu WM, Chen CH, Kuo CC. Chen HH, et al. Among authors: chang hh, chang jy. Chem Res Toxicol. 2015 Sep 21;28(9):1681-92. doi: 10.1021/acs.chemrestox.5b00085. Epub 2015 Aug 24. Chem Res Toxicol. 2015. PMID: 26275128
Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells.
Chen HH, Chang HH, Chang JY, Tang YC, Cheng YC, Lin LM, Cheng SY, Huang CH, Sun MW, Chen CT, Kuo CC. Chen HH, et al. Among authors: chang hh, chang jy. Free Radic Biol Med. 2017 Dec;113:505-518. doi: 10.1016/j.freeradbiomed.2017.10.375. Epub 2017 Nov 5. Free Radic Biol Med. 2017. PMID: 29080842
4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy.
Lin SY, Yeh TK, Song JS, Hung MS, Cheng MF, Liao FY, Li AS, Cheng SY, Lin LM, Chiu CH, Wu MH, Lin YJ, Hsiao W, Sun M, Wang YH, Huang CH, Tang YC, Chang HH, Huang ZT, Chao YS, Shih C, Pan SL, Wu SY, Kuo CC, Ueng SH. Lin SY, et al. Among authors: chang hh. Bioorg Chem. 2018 Apr;77:600-607. doi: 10.1016/j.bioorg.2018.02.010. Epub 2018 Feb 12. Bioorg Chem. 2018. PMID: 29494816
Development of Potent and Selective Inhibitors of Methylenetetrahydrofolate Dehydrogenase 2 for Targeting Acute Myeloid Leukemia: SAR, Structural Insights, and Biological Characterization.
Chang HH, Lee LC, Hsu T, Peng YH, Huang CH, Yeh TK, Lu CT, Huang ZT, Hsueh CC, Kung FC, Lin LM, Huang YC, Wang YH, Li LH, Tang YC, Chang L, Hsieh CC, Jiaang WT, Kuo CC, Wu SY. Chang HH, et al. Among authors: chang l. J Med Chem. 2024 Dec 12;67(23):21106-21125. doi: 10.1021/acs.jmedchem.4c01775. Epub 2024 Nov 26. J Med Chem. 2024. PMID: 39591507 Free PMC article.
1,702 results