Zhang D - Search Results

1

The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression.

Li X, Li J, Huang Y, Gong Q, Fu Y, Xu Y, Huang J, You H, Zhang D, Zhang D, Mao F, Zhu J, Wang H, Zhang H, Li J. Li X, et al. Among authors: zhang d, zhang h. Eur J Med Chem. 2022 Feb 5;229:114045. doi: 10.1016/j.ejmech.2021.114045. Epub 2021 Dec 7. Eur J Med Chem. 2022. PMID: 34922191

2

Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate.

Zhou Y, Fu Y, Yin W, Li J, Wang W, Bai F, Xu S, Gong Q, Peng T, Hong Y, Zhang D, Zhang D, Liu Q, Xu Y, Xu HE, Zhang H, Jiang H, Liu H. Zhou Y, et al. Among authors: zhang d, zhang h. J Med Chem. 2021 Feb 25;64(4):1844-1855. doi: 10.1021/acs.jmedchem.0c01863. Epub 2021 Feb 11. J Med Chem. 2021. PMID: 33570950

3

Design, synthesis, and evaluation of isoflavone analogs as multifunctional agents for the treatment of Alzheimer's disease.

Wang D, Hu M, Li X, Zhang D, Chen C, Fu J, Shao S, Shi G, Zhou Y, Wu S, Zhang T. Wang D, et al. Among authors: zhang d, zhang t. Eur J Med Chem. 2019 Apr 15;168:207-220. doi: 10.1016/j.ejmech.2019.02.053. Epub 2019 Feb 20. Eur J Med Chem. 2019. PMID: 30822710

4

Design, Synthesis, and Biological Evaluation of Novel Tetrahydroprotoberberine Derivatives (THPBs) as Selective α_1A-Adrenoceptor Antagonists.

Guo D, Li J, Lin H, Zhou Y, Chen Y, Zhao F, Sun H, Zhang D, Li H, Shoichet BK, Shan L, Zhang W, Xie X, Jiang H, Liu H. Guo D, et al. Among authors: zhang w, zhang d. J Med Chem. 2016 Oct 27;59(20):9489-9502. doi: 10.1021/acs.jmedchem.6b01217. Epub 2016 Oct 12. J Med Chem. 2016. PMID: 27709945

5

Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening.

Ma GH, Ye Y, Zhang D, Xu X, Si P, Peng JL, Xiao YL, Cao RY, Yin YL, Chen J, Zhao LX, Zhou Y, Zhong W, Liu H, Luo XM, Chen LL, Shen X. Ma GH, et al. Among authors: zhang d. Eur J Med Chem. 2016 Nov 29;124:981-991. doi: 10.1016/j.ejmech.2016.10.019. Epub 2016 Oct 11. Eur J Med Chem. 2016. PMID: 27776325

6

Discovery of coumarin Mannich base derivatives as multifunctional agents against monoamine oxidase B and neuroinflammation for the treatment of Parkinson's disease.

Tao D, Wang Y, Bao XQ, Yang BB, Gao F, Wang L, Zhang D, Li L. Tao D, et al. Among authors: zhang d. Eur J Med Chem. 2019 Jul 1;173:203-212. doi: 10.1016/j.ejmech.2019.04.016. Epub 2019 Apr 12. Eur J Med Chem. 2019. PMID: 31005056

7

A Novel Parkinson's Disease Drug Candidate with Potent Anti-neuroinflammatory Effects through the Src Signaling Pathway.

Wang YD, Bao XQ, Xu S, Yu WW, Cao SN, Hu JP, Li Y, Wang XL, Zhang D, Yu SS. Wang YD, et al. Among authors: zhang d. J Med Chem. 2016 Oct 13;59(19):9062-9079. doi: 10.1021/acs.jmedchem.6b00976. Epub 2016 Sep 27. J Med Chem. 2016. PMID: 27617803

8

Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors.

Lu W, Wang J, Li Y, Tao H, Xiong H, Lian F, Gao J, Ma H, Lu T, Zhang D, Ye X, Ding H, Yue L, Zhang Y, Tang H, Zhang N, Yang Y, Jiang H, Chen K, Zhou B, Luo C. Lu W, et al. Among authors: zhang n, zhang d, zhang y. Eur J Med Chem. 2019 Dec 15;184:111767. doi: 10.1016/j.ejmech.2019.111767. Epub 2019 Oct 9. Eur J Med Chem. 2019. PMID: 31622854

9

Discovery of Thieno[2,3-e]indazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability.

Lu Z, Cao Y, Zhang D, Meng X, Guo B, Kong D, Yang Y. Lu Z, et al. Among authors: zhang d. J Med Chem. 2022 Apr 14;65(7):5724-5750. doi: 10.1021/acs.jmedchem.2c00008. Epub 2022 Mar 31. J Med Chem. 2022. PMID: 35357160

10

Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening.

Zhang D, Han J, Lu W, Lian F, Wang J, Lu T, Tao H, Xiao S, Zhang F, Liu YC, Liu R, Zhang N, Jiang H, Chen K, Zhao C, Luo C. Zhang D, et al. Among authors: zhang n, zhang f. Bioorg Chem. 2019 May;86:494-500. doi: 10.1016/j.bioorg.2019.01.035. Epub 2019 Jan 28. Bioorg Chem. 2019. PMID: 30780018

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