Huang Y - Search Results

1

The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression.

Li X, Li J, Huang Y, Gong Q, Fu Y, Xu Y, Huang J, You H, Zhang D, Zhang D, Mao F, Zhu J, Wang H, Zhang H, Li J. Li X, et al. Among authors: huang j, huang y. Eur J Med Chem. 2022 Feb 5;229:114045. doi: 10.1016/j.ejmech.2021.114045. Epub 2021 Dec 7. Eur J Med Chem. 2022. PMID: 34922191

2

Discovery of novel allosteric site and covalent inhibitors of FBPase with potent hypoglycemic effects.

Huang Y, Wei L, Han X, Chen H, Ren Y, Xu Y, Song R, Rao L, Su C, Peng C, Feng L, Wan J. Huang Y, et al. Eur J Med Chem. 2019 Dec 15;184:111749. doi: 10.1016/j.ejmech.2019.111749. Epub 2019 Sep 30. Eur J Med Chem. 2019. PMID: 31589992

3

Identification of the New Covalent Allosteric Binding Site of Fructose-1,6-bisphosphatase with Disulfiram Derivatives toward Glucose Reduction.

Huang Y, Xu Y, Song R, Ni S, Liu J, Xu Y, Ren Y, Rao L, Wang Y, Wei L, Feng L, Su C, Peng C, Li J, Wan J. Huang Y, et al. J Med Chem. 2020 Jun 11;63(11):6238-6247. doi: 10.1021/acs.jmedchem.0c00699. Epub 2020 May 19. J Med Chem. 2020. PMID: 32375478

4

Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes.

Xu YX, Huang YY, Song RR, Ren YL, Chen X, Zhang C, Mao F, Li XK, Zhu J, Ni SS, Wan J, Li J. Xu YX, et al. Eur J Med Chem. 2020 Oct 1;203:112500. doi: 10.1016/j.ejmech.2020.112500. Epub 2020 Jul 15. Eur J Med Chem. 2020. PMID: 32711108

5

Rapid Repurposing of Novel Combination Drugs for the Treatment of Heart Failure via a Computationally Guided Network Screening Approach.

Huang Y, Wang J, Liu J, Shi D, Li X, Wang M, Lu T, Jiang B, Xia C, Lin H, Xu Y, Li J. Huang Y, et al. J Chem Inf Model. 2022 Nov 14;62(21):5223-5232. doi: 10.1021/acs.jcim.1c00132. Epub 2021 Jun 20. J Chem Inf Model. 2022. PMID: 34151561

6

Anti-aging effects of chlorpropamide depend on mitochondrial complex-II and the production of mitochondrial reactive oxygen species.

Mao Z, Liu W, Huang Y, Sun T, Bao K, Feng J, Moskalev A, Hu Z, Li J. Mao Z, et al. Among authors: huang y. Acta Pharm Sin B. 2022 Feb;12(2):665-677. doi: 10.1016/j.apsb.2021.08.007. Epub 2021 Aug 10. Acta Pharm Sin B. 2022. PMID: 35256938 Free PMC article.

7

Identification of Guaifenesin-Andrographolide as a Novel Combinatorial Drug Therapy for Epilepsy Using Network Virtual Screening and Experimental Validation.

Huang Y, Xu H, Wang P, Gu R, Li X, Xu Y, Wang J, Qiao S, Shi D, Gao Z, Li J. Huang Y, et al. ACS Chem Neurosci. 2022 Apr 6;13(7):978-986. doi: 10.1021/acschemneuro.1c00774. Epub 2022 Mar 25. ACS Chem Neurosci. 2022. PMID: 35333519

8

Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer's disease and depression.

Zhang C, Wang L, Xu Y, Huang Y, Huang J, Zhu J, Wang W, Li W, Sun A, Li X, Zhang H, Li J. Zhang C, et al. Among authors: huang j, huang y. Eur J Med Chem. 2022 Jun 5;236:114347. doi: 10.1016/j.ejmech.2022.114347. Epub 2022 Apr 6. Eur J Med Chem. 2022. PMID: 35430560

9

N-Acylamino Saccharin as an Emerging Cysteine-Directed Covalent Warhead and Its Application in the Identification of Novel FBPase Inhibitors toward Glucose Reduction.

Wen W, Cao H, Xu Y, Ren Y, Rao L, Shao X, Chen H, Wu L, Liu J, Su C, Peng C, Huang Y, Wan J. Wen W, et al. Among authors: huang y. J Med Chem. 2022 Jul 14;65(13):9126-9143. doi: 10.1021/acs.jmedchem.2c00336. Epub 2022 Jul 4. J Med Chem. 2022. PMID: 35786925

10

Photoactivatable senolysis with single-cell resolution delays aging.

Shi D, Liu W, Gao Y, Li X, Huang Y, Li X, James TD, Guo Y, Li J. Shi D, et al. Among authors: huang y. Nat Aging. 2023 Mar;3(3):297-312. doi: 10.1038/s43587-023-00360-x. Epub 2023 Feb 2. Nat Aging. 2023. PMID: 37118423

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