Lusvarghi S - Search Results

1

Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter.

Robey RW, Robinson AN, Ali-Rahmani F, Huff LM, Lusvarghi S, Vahedi S, Hotz JM, Warner AC, Butcher D, Matta J, Edmondson EF, Lee TD, Roth JS, Lee OW, Shen M, Tanner K, Hall MD, Ambudkar SV, Gottesman MM. Robey RW, et al. Among authors: lusvarghi s. Sci Rep. 2021 Dec 17;11(1):24150. doi: 10.1038/s41598-021-03500-8. Sci Rep. 2021. PMID: 34921178 Free PMC article.

2

Mapping discontinuous epitopes for MRK-16, UIC2 and 4E3 antibodies to extracellular loops 1 and 4 of human P-glycoprotein.

Vahedi S, Lusvarghi S, Pluchino K, Shafrir Y, Durell SR, Gottesman MM, Ambudkar SV. Vahedi S, et al. Among authors: lusvarghi s. Sci Rep. 2018 Aug 24;8(1):12716. doi: 10.1038/s41598-018-30984-8. Sci Rep. 2018. PMID: 30143707 Free PMC article.

3

Evidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1).

Sajid A, Lusvarghi S, Chufan EE, Ambudkar SV. Sajid A, et al. Among authors: lusvarghi s. PLoS One. 2018 Sep 28;13(9):e0204693. doi: 10.1371/journal.pone.0204693. eCollection 2018. PLoS One. 2018. PMID: 30265721 Free PMC article.

4

The FLT3 inhibitor midostaurin selectively resensitizes ABCB1-overexpressing multidrug-resistant cancer cells to conventional chemotherapeutic agents.

Hsiao SH, Lusvarghi S, Huang YH, Ambudkar SV, Hsu SC, Wu CP. Hsiao SH, et al. Among authors: lusvarghi s. Cancer Lett. 2019 Mar 31;445:34-44. doi: 10.1016/j.canlet.2019.01.001. Epub 2019 Jan 11. Cancer Lett. 2019. PMID: 30639533 Free PMC article.

5

Large-scale purification of functional human P-glycoprotein (ABCB1).

Nandigama K, Lusvarghi S, Shukla S, Ambudkar SV. Nandigama K, et al. Among authors: lusvarghi s. Protein Expr Purif. 2019 Jul;159:60-68. doi: 10.1016/j.pep.2019.03.002. Epub 2019 Mar 6. Protein Expr Purif. 2019. PMID: 30851394 Free PMC article.

6

Avapritinib: A Selective Inhibitor of KIT and PDGFRα that Reverses ABCB1 and ABCG2-Mediated Multidrug Resistance in Cancer Cell Lines.

Wu CP, Lusvarghi S, Wang JC, Hsiao SH, Huang YH, Hung TH, Ambudkar SV. Wu CP, et al. Among authors: lusvarghi s. Mol Pharm. 2019 Jul 1;16(7):3040-3052. doi: 10.1021/acs.molpharmaceut.9b00274. Epub 2019 Jun 4. Mol Pharm. 2019. PMID: 31117741 Free PMC article.

7

Synthesis and Characterization of Bodipy-FL-Cyclosporine A as a Substrate for Multidrug Resistance-Linked P-Glycoprotein (ABCB1).

Sajid A, Raju N, Lusvarghi S, Vahedi S, Swenson RE, Ambudkar SV. Sajid A, et al. Among authors: lusvarghi s. Drug Metab Dispos. 2019 Oct;47(10):1013-1023. doi: 10.1124/dmd.119.087734. Epub 2019 Aug 1. Drug Metab Dispos. 2019. PMID: 31371421 Free PMC article.

8

A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.

Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD. Lee TD, et al. Among authors: lusvarghi s. Mol Pharmacol. 2019 Nov;96(5):629-640. doi: 10.1124/mol.119.115964. Epub 2019 Sep 12. Mol Pharmacol. 2019. PMID: 31515284 Free PMC article.

9

ABC-transporter upregulation mediates resistance to the CDK7 inhibitors THZ1 and ICEC0942.

Sava GP, Fan H, Fisher RA, Lusvarghi S, Pancholi S, Ambudkar SV, Martin LA, Charles Coombes R, Buluwela L, Ali S. Sava GP, et al. Among authors: lusvarghi s. Oncogene. 2020 Jan;39(3):651-663. doi: 10.1038/s41388-019-1008-y. Epub 2019 Sep 17. Oncogene. 2020. PMID: 31530935 Free PMC article.

10

ATP-dependent thermostabilization of human P-glycoprotein (ABCB1) is blocked by modulators.

Lusvarghi S, Ambudkar SV. Lusvarghi S, et al. Biochem J. 2019 Dec 19;476(24):3737-3750. doi: 10.1042/BCJ20190736. Biochem J. 2019. PMID: 31774117 Free PMC article.

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