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A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques.
Zhang XJ, Ji YX, Cheng X, Cheng Y, Yang H, Wang J, Zhao LP, Huang YP, Sun D, Xiang H, Shen LJ, Li PL, Ma JP, Tian RF, Yang J, Yao X, Xu H, Liao R, Xiao L, Zhang P, Zhang X, Zhao GN, Wang X, Hu ML, Tian S, Wan J, Cai J, Ma X, Xu Q, Wang Y, Touyz RM, Liu PP, Loomba R, She ZG, Li H. Zhang XJ, et al. Among authors: yang h, yang j. Sci Transl Med. 2021 Dec 15;13(624):eabg8116. doi: 10.1126/scitranslmed.abg8116. Epub 2021 Dec 15. Sci Transl Med. 2021. PMID: 34910548
Global Burden of Disease Study 2019 suggests that metabolic risk factors are the leading drivers of the burden of ischemic heart disease.
Wang W, Hu M, Liu H, Zhang X, Li H, Zhou F, Liu YM, Lei F, Qin JJ, Zhao YC, Chen Z, Liu W, Song X, Huang X, Zhu L, Ji YX, Zhang P, Zhang XJ, She ZG, Yang J, Yang H, Cai J, Li H. Wang W, et al. Among authors: yang h, yang j. Cell Metab. 2021 Oct 5;33(10):1943-1956.e2. doi: 10.1016/j.cmet.2021.08.005. Epub 2021 Sep 2. Cell Metab. 2021. PMID: 34478633 Free article.
Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species.
Zhang XJ, Liu X, Hu M, Zhao GJ, Sun D, Cheng X, Xiang H, Huang YP, Tian RF, Shen LJ, Ma JP, Wang HP, Tian S, Gan S, Xu H, Liao R, Zou T, Ji YX, Zhang P, Cai J, Wang ZV, Meng G, Xu Q, Wang Y, Ma XL, Liu PP, Huang Z, Zhu L, She ZG, Zhang X, Bai L, Yang H, Lu Z, Li H. Zhang XJ, et al. Among authors: yang h. Cell Metab. 2021 Oct 5;33(10):2059-2075.e10. doi: 10.1016/j.cmet.2021.08.014. Epub 2021 Sep 17. Cell Metab. 2021. PMID: 34536344 Free article.
A high-throughput drug screening identifies luteolin as a therapeutic candidate for pathological cardiac hypertrophy and heart failure.
Wang Z, Shi W, Wu T, Peng T, Wang X, Liu S, Yang Z, Wang J, Li PL, Tian R, Hong Y, Yang H, Bai L, Hu Y, Cheng X, Li H, Zhang XJ, She ZG. Wang Z, et al. Among authors: yang h, yang z. Front Cardiovasc Med. 2023 Mar 14;10:1130635. doi: 10.3389/fcvm.2023.1130635. eCollection 2023. Front Cardiovasc Med. 2023. PMID: 36998980 Free PMC article.
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