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A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques.
Zhang XJ, Ji YX, Cheng X, Cheng Y, Yang H, Wang J, Zhao LP, Huang YP, Sun D, Xiang H, Shen LJ, Li PL, Ma JP, Tian RF, Yang J, Yao X, Xu H, Liao R, Xiao L, Zhang P, Zhang X, Zhao GN, Wang X, Hu ML, Tian S, Wan J, Cai J, Ma X, Xu Q, Wang Y, Touyz RM, Liu PP, Loomba R, She ZG, Li H. Zhang XJ, et al. Among authors: shen lj. Sci Transl Med. 2021 Dec 15;13(624):eabg8116. doi: 10.1126/scitranslmed.abg8116. Epub 2021 Dec 15. Sci Transl Med. 2021. PMID: 34910548
Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4.
Zhao GN, Zhang P, Gong J, Zhang XJ, Wang PX, Yin M, Jiang Z, Shen LJ, Ji YX, Tong J, Wang Y, Wei QF, Wang Y, Zhu XY, Zhang X, Fang J, Xie Q, She ZG, Wang Z, Huang Z, Li H. Zhao GN, et al. Among authors: shen lj. Nat Med. 2017 Jun;23(6):742-752. doi: 10.1038/nm.4334. Epub 2017 May 8. Nat Med. 2017. PMID: 28481357
Wang et al. reply.
Wang PX, Zhao GN, Ji YX, Zhang P, Zhang XJ, Gong J, Zhao LP, Yan ZZ, Yin M, Jiang Z, Shen LJ, Yang X, Fang J, Tian S, Tong J, Wang Y, Zhu XY, Zhang X, Wei QF, Wang Y, Xie Q, Li J, Wan L, She ZG, Wang Z, Huang Z, Li H. Wang PX, et al. Among authors: shen lj. Nat Med. 2018 Jun;24(6):700-701. doi: 10.1038/s41591-018-0063-1. Nat Med. 2018. PMID: 29867231 No abstract available.
355 results