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A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques.
Zhang XJ, Ji YX, Cheng X, Cheng Y, Yang H, Wang J, Zhao LP, Huang YP, Sun D, Xiang H, Shen LJ, Li PL, Ma JP, Tian RF, Yang J, Yao X, Xu H, Liao R, Xiao L, Zhang P, Zhang X, Zhao GN, Wang X, Hu ML, Tian S, Wan J, Cai J, Ma X, Xu Q, Wang Y, Touyz RM, Liu PP, Loomba R, She ZG, Li H. Zhang XJ, et al. Among authors: hu ml. Sci Transl Med. 2021 Dec 15;13(624):eabg8116. doi: 10.1126/scitranslmed.abg8116. Epub 2021 Dec 15. Sci Transl Med. 2021. PMID: 34910548
Hepatocyte SH3RF2 Deficiency Is a Key Aggravator for NAFLD.
Yang X, Sun D, Xiang H, Wang S, Huang Y, Li L, Cheng X, Liu H, Hu F, Cheng Y, Ma T, Hu M, Tian H, Tian S, Zhou Y, Zhang P, Zhang XJ, Ji YX, Hu Y, Li H, She ZG. Yang X, et al. Hepatology. 2021 Sep;74(3):1319-1338. doi: 10.1002/hep.31863. Epub 2021 Aug 30. Hepatology. 2021. PMID: 33894019
TMBIM1 is an inhibitor of adipogenesis and its depletion promotes adipocyte hyperplasia and improves obesity-related metabolic disease.
Zhao GN, Tian ZW, Tian T, Zhu ZP, Zhao WJ, Tian H, Cheng X, Hu FJ, Hu ML, Tian S, Ding T, Chen S, Ji YX, Zhang P, Zhang XJ, She ZG, Yuan Y, Chen W, Bai L, Li H. Zhao GN, et al. Among authors: hu fj, hu ml. Cell Metab. 2021 Aug 3;33(8):1640-1654.e8. doi: 10.1016/j.cmet.2021.05.014. Epub 2021 Jun 8. Cell Metab. 2021. PMID: 34107313 Free article.
369 results